Joint Associations of Physical Activity and Hypertension with the Development of Type 2 Diabetes among Urban Men and Women in Mainland China

Xu, Fei, Ware, Robert S., Tse, Lap Ah, Wang, YouFa, Wang, ZhiYong, Hong, Xin, Chan, Emily Ying Yang, Dunstan, David W. and Owen, Neville (2014) Joint Associations of Physical Activity and Hypertension with the Development of Type 2 Diabetes among Urban Men and Women in Mainland China. PLoS One, 9 2: e88719.1-e88719.6. doi:10.1371/journal.pone.0088719


Author Xu, Fei
Ware, Robert S.
Tse, Lap Ah
Wang, YouFa
Wang, ZhiYong
Hong, Xin
Chan, Emily Ying Yang
Dunstan, David W.
Owen, Neville
Title Joint Associations of Physical Activity and Hypertension with the Development of Type 2 Diabetes among Urban Men and Women in Mainland China
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2014-02-01
Year available 2014
Sub-type Article (original research)
DOI 10.1371/journal.pone.0088719
Open Access Status DOI
Volume 9
Issue 2
Start page e88719.1
End page e88719.6
Total pages 6
Place of publication San Francisco, CA United States
Publisher Public Library of Science
Language eng
Abstract Background: Physical activity (PA) and hypertension (HTN) are important influences on the development of type 2 diabetes (T2D). However, the joint impact of PA and HTN on T2D development is unknown.
Formatted abstract
Background
Physical activity (PA) and hypertension (HTN) are important influences on the development of type 2 diabetes (T2D). However, the joint impact of PA and HTN on T2D development is unknown.

Methods
Two community-based prospective cohort studies, with the same protocols, instruments and questionnaires, were conducted among adults in urban areas of Nanjing, China, during 2004–2007 and 2007–2010. T2D was defined using World Health Organization criteria based on physicians' diagnosis and fasting blood glucose concentration. PA level (sufficient/insufficient) and blood pressure status (hypertensive/normotensive) were assessed at baseline and the third year of follow-up. We pooled and analyzed data from these two studies.

Results
Among 4550 participants aged 35 years or older, the three-year cumulative incidence of T2D was 5.1%. After adjusting for potential confounders, participants with sufficient PA were less likely to develop T2D than those with insufficient PA (OR = 0.43, 95%CI = 0.27, 0.68) and those who were normotensive were less likely to develop T2D than those who were hypertensive (OR = 0.39, 95%CI = 0.29, 0.51). Compared to participants with insufficient PA and who were hypertensive, those with sufficient PA and hypertension were at lower risk of developing T2D (OR = 0.36, 95%CI = 0.19, 0.69), as were those with insufficient PA who were normotensive (OR = 0.37, 95%CI = 0.28, 0.50) and those with sufficient PA who were normotensive (OR = 0.19, 95%CI = 0.10, 0.37).

Conclusions
Insufficient PA was found to be associated with the development of T2D among adults with and without hypertension. These findings support a role for promoting higher physical activity levels to lower T2D risk in both hypertensive and non-hypertensive individuals 
Keyword United States
Prevalence
Risk
Reliability
Pressure
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID QRX11038
2003-ZKK0310
2003-BS200231
JS-2010-109
569940
1003960
FT100100918
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Public Health Publications
 
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