Fitness, fatness, and survival in adults with prediabetes

McAuley, Paul A., Artero, Enrique G., Sui, Xuemei, Lavie, Carl J., Almeida, M. Joao and Blair, Steven N. (2014) Fitness, fatness, and survival in adults with prediabetes. Diabetes Care, 37 2: 529-536. doi:10.2337/dc13-1347

Author McAuley, Paul A.
Artero, Enrique G.
Sui, Xuemei
Lavie, Carl J.
Almeida, M. Joao
Blair, Steven N.
Title Fitness, fatness, and survival in adults with prediabetes
Journal name Diabetes Care   Check publisher's open access policy
ISSN 0149-5992
Publication date 2014-02-01
Year available 2013
Sub-type Article (original research)
DOI 10.2337/dc13-1347
Open Access Status DOI
Volume 37
Issue 2
Start page 529
End page 536
Total pages 8
Place of publication Alexandria, United States
Publisher American Diabetes Association
Language eng
Formatted abstract
OBJECTIVE The purpose of this study was to examine independent and joint associations of cardiorespiratory fitness (CRF) and different adiposity measures with mortality risk in individuals with prediabetes (or impaired fasting glucose).

RESEARCH DESIGN AND METHODS We examined associations of CRF and fatness with cardiovascular disease (CVD) and all-cause mortality in a cohort of 17,044 participants (89% men) with prediabetes (defined as 100 mg/dL £ fasting plasma glucose < 126 mg/dL), who did not have a history of diabetes, CVD, or cancer.

RESULTS We identified 832 deaths (246 from CVD) during 13.9 6 7.0 years (mean 6 SD) follow-up. Normal-weight individuals who were unfit (lowest one-third) had a higher risk of all-cause (hazard ratio 1.70 [95% CI 1.32-2.18]) and CVD (1.88 [1.13- 3.10]) mortality compared with the normal-weight and fit (upper two-thirds) reference group in a model adjusted for age, sex, examination year, and multiple risk factors. The mortality risk for fit individuals who were overweight or obese did not differ significantly from the reference group. Similar patterns were observed for sex-specific thirds of waist circumference and % body fat.

CONCLUSIONS CRF markedly modifies the relationship between adiposity and mortality in persons with prediabetes. Unfit individuals have a higher and fit individuals have a lower mortality risk irrespective of adiposity level in this high-risk group.
Keyword Endocrinology & Metabolism
Endocrinology & Metabolism
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID AG-06945
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Medicine Publications
Official 2015 Collection
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Citation counts: TR Web of Science Citation Count  Cited 17 times in Thomson Reuters Web of Science Article | Citations
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