Programmable drug release using bioresponsive mesoporous silica nanoparticles for site-specific oral drug delivery

Popat, Amirali, Jambhrunkar, Siddharth, Zhang, Jun, Yang, Jie, Zhang, Honwei, Meka, Anand and Yu, Chengzhong (2014) Programmable drug release using bioresponsive mesoporous silica nanoparticles for site-specific oral drug delivery. Chemical Communications, 50 42: 5547-5550. doi:10.1039/C4CC00620H


Author Popat, Amirali
Jambhrunkar, Siddharth
Zhang, Jun
Yang, Jie
Zhang, Honwei
Meka, Anand
Yu, Chengzhong
Title Programmable drug release using bioresponsive mesoporous silica nanoparticles for site-specific oral drug delivery
Journal name Chemical Communications   Check publisher's open access policy
ISSN 1359-7345
1364-548X
Publication date 2014-02-17
Year available 2014
Sub-type Article (original research)
DOI 10.1039/C4CC00620H
Open Access Status DOI
Volume 50
Issue 42
Start page 5547
End page 5550
Total pages 4
Place of publication Cambridge, United Kingdom
Publisher R S C Publications
Language eng
Abstract Novel mesoporous silica nanoparticles (MSNs) responsive to multiple biological stimuli (pH and enzymes) were prepared through conjugation with a structure modified soy protein isolate. The particles show an extremely high pro-drug (sulfasalazine) loading with programmable drug release in simulated gastrointestinal fluid.
Formatted abstract
Novel mesoporous silica nanoparticles (MSNs) responsive to multiple biological stimuli (pH and enzymes) were prepared through conjugation with a structure modified soy protein isolate. The particles show an extremely high pro-drug (sulfasalazine) loading with programmable drug release in simulated gastrointestinal fluid.
Keyword Chemistry, Multidisciplinary
Chemistry
CHEMISTRY, MULTIDISCIPLINARY
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Sat, 22 Mar 2014, 23:38:26 EST by Mr Amirali Popat on behalf of Aust Institute for Bioengineering & Nanotechnology