Layer-specific diffusion weighted imaging in human primary visual cortex invitro

Kleinnijenhuis, Michiel, Zerbi, Valerio, Kusters, Benno, Slump, Cornelis H., Barth, Markus and van Cappellen van Walsum, Anne-Marie (2013) Layer-specific diffusion weighted imaging in human primary visual cortex invitro. Cortex, 49 9: 2569-2582. doi:10.1016/j.cortex.2012.11.015

Author Kleinnijenhuis, Michiel
Zerbi, Valerio
Kusters, Benno
Slump, Cornelis H.
Barth, Markus
van Cappellen van Walsum, Anne-Marie
Title Layer-specific diffusion weighted imaging in human primary visual cortex invitro
Journal name Cortex   Check publisher's open access policy
ISSN 0010-9452
Publication date 2013-10-01
Year available 2012
Sub-type Article (original research)
DOI 10.1016/j.cortex.2012.11.015
Open Access Status Not yet assessed
Volume 49
Issue 9
Start page 2569
End page 2582
Total pages 14
Place of publication Milan, Italy
Publisher Elsevier Masson
Language eng
Formatted abstract
One of the most prominent characteristics of the human neocortex is its laminated structure. The first person to observe this was Francesco Gennari in the second half the 18th century: in the middle of the depth of primary visual cortex, myelinated fibres are so abundant that he could observe them with bare eyes as a white line. Because of its saliency, the stria of Gennari has a rich history in cyto- and myeloarchitectural research as well as in magnetic resonance (MR) microscopy. In the present paper we show for the first time the layered structure of the human neocortex with exvivo diffusion weighted imaging (DWI). To achieve the necessary spatial and angular resolution, primary visual cortex samples were scanned on an 11.7T small-animal MR system to characterize the diffusion properties of the cortical laminae and the stria of Gennari in particular. The results demonstrated that fractional anisotropy varied over cortical depth, showing reduced anisotropy in the stria of Gennari, the inner band of Baillarger and the deepest layer of the cortex. Orientation density functions showed multiple components in the stria of Gennari and deeper layers of the cortex. Potential applications of layer-specific diffusion imaging include characterization of clinical abnormalities, cortical mapping and (intra)cortical tractography. We conclude that future high-resolution invivo cortical DWI investigations should take into account the layer-specificity of the diffusion properties.
Keyword Cortical anisotropy
Diffusion weighted imaging
Primary visual cortex
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 40-00506-90-0602
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
Centre for Advanced Imaging Publications
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Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 20 Mar 2014, 19:18:02 EST by Ms Kate Rowe on behalf of Centre for Advanced Imaging