Influence of fMRI smoothing procedures on replicability of fine scale motor localization

Geissler, Alexander, Lanzenberger, Rupert, Barth, Markus, Tahamtan, Amir Reza, Milakara, Denny, Gartus, Andreas and Beisteiner, Roland (2005) Influence of fMRI smoothing procedures on replicability of fine scale motor localization. NeuroImage, 24 2: 323-331. doi:10.1016/j.neuroimage.2004.08.042

Author Geissler, Alexander
Lanzenberger, Rupert
Barth, Markus
Tahamtan, Amir Reza
Milakara, Denny
Gartus, Andreas
Beisteiner, Roland
Title Influence of fMRI smoothing procedures on replicability of fine scale motor localization
Journal name NeuroImage   Check publisher's open access policy
ISSN 1053-8119
Publication date 2005-01-15
Year available 2004
Sub-type Article (original research)
DOI 10.1016/j.neuroimage.2004.08.042
Open Access Status Not yet assessed
Volume 24
Issue 2
Start page 323
End page 331
Total pages 9
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Language eng
Abstract Recent publications analyzing the influence of spatial smoothing on fMRI brain activation results demonstrated that smoothing may artificially combine activations from adjacent though functionally and anatomically distinct brain regions and that activation from large draining vessels may be smoothed into neighboring neuronal tissue. To investigate whether functional localizations may be artificially shifted by the smoothing procedure we performed replicability measurements. Localization centers of motor hand activations achieved during different conditions (isolated hand movements and simultaneous hand and chin movements) were compared with respect to smoothing effects. The voxel with the highest probability to represent a true positive activation was localized with a non-smoothed and a standard 4 × 4 × 6 mm smoothed correlational data analysis technique. Results show an increase of motor center aberrations between measurements by about 100% due to data smoothing indicating a statistically significant decrease in localization replicability.
Keyword Data smoothing
Functional resolution
Motor localization
Normal subjects
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Centre for Advanced Imaging Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 35 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 39 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 20 Mar 2014, 18:30:14 EST by System User on behalf of Learning and Research Services (UQ Library)