Comparison of fMRI coregistration results between human experts and software solutions in patients and healthy subjects

Gartus, Andreas, Geissler, Alexander, Foki, Thomas, Tahamtan, Amir Reza, Pahs, Gerald, Barth, Markus, Pinker, Katja, Trattnig, Siegfried and Beisteiner, Roland (2007) Comparison of fMRI coregistration results between human experts and software solutions in patients and healthy subjects. European Radiology, 17 6: 1634-1643. doi:10.1007/s00330-006-0459-z


Author Gartus, Andreas
Geissler, Alexander
Foki, Thomas
Tahamtan, Amir Reza
Pahs, Gerald
Barth, Markus
Pinker, Katja
Trattnig, Siegfried
Beisteiner, Roland
Title Comparison of fMRI coregistration results between human experts and software solutions in patients and healthy subjects
Journal name European Radiology   Check publisher's open access policy
ISSN 0938-7994
1432-1084
Publication date 2007-06-01
Year available 2006
Sub-type Article (original research)
DOI 10.1007/s00330-006-0459-z
Open Access Status Not yet assessed
Volume 17
Issue 6
Start page 1634
End page 1643
Total pages 10
Place of publication Heidelberg, Germany
Publisher Springer
Language eng
Abstract Functional magnetic resonance imaging (fMRI) performed by echo-planar imaging (EPI) is often highly distorted, and it is therefore necessary to coregister the functional to undistorted anatomical images, especially for clinical applications. This pilot study provides an evaluation of human and automatic coregistration results in the human motor cortex of normal and pathological brains. Ten healthy right-handed subjects and ten right-handed patients performed simple right hand movements during fMRI. A reference point chosen at a characteristic anatomical location within the fMRI sensorimotor activations was transferred to the high resolution anatomical MRI images by three human fMRI experts and by three automatic coregistration programs. The 3D distance between the median localizations of experts and programs was calculated and compared between patients and healthy subjects. Results show that fMRI localization on anatomical images was better with the experts than software in 70% of the cases and that software performance was worse for patients than healthy subjects (unpaired t-test: P=0.040). With 45.6 mm the maximum disagreement between experts and software was quite large. The inter-rater consistency was better for the fMRI experts compared to the coregistration programs (ANOVA: P=0.003). We conclude that results of automatic coregistration should be evaluated carefully, especially in case of clinical application.
Keyword 3D linear coregistration
Clinical brain mapping
Functional MRI
Healthy subjects
Patients
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Centre for Advanced Imaging Publications
 
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