T1 mapping of the entire lung parenchyma: Influence of respiratory phase and correlation to lung function test results in patients with diffuse lung disease

Stadler, Alfred, Jakob, Peter M., Griswold, Mark, Stiebellehner, Leopold, Barth, Markus and Bankier, Alexander A. (2008) T1 mapping of the entire lung parenchyma: Influence of respiratory phase and correlation to lung function test results in patients with diffuse lung disease. Magnetic Resonance in Medicine, 59 1: 96-101. doi:10.1002/mrm.21446


Author Stadler, Alfred
Jakob, Peter M.
Griswold, Mark
Stiebellehner, Leopold
Barth, Markus
Bankier, Alexander A.
Title T1 mapping of the entire lung parenchyma: Influence of respiratory phase and correlation to lung function test results in patients with diffuse lung disease
Journal name Magnetic Resonance in Medicine   Check publisher's open access policy
ISSN 0740-3194
1522-2594
Publication date 2008-01-01
Year available 2008
Sub-type Article (original research)
DOI 10.1002/mrm.21446
Volume 59
Issue 1
Start page 96
End page 101
Total pages 6
Place of publication Hoboken, NJ United State
Publisher John Wiley and Sons, Inc.
Language eng
Subject 2741 Radiology Nuclear Medicine and imaging
3614 Radiological and Ultrasound Technology
Abstract The T1 values of lung parenchyma of 25 patients with fibrosis and emphysema were measured in the entire lung, and the effect of inspiration and expiration was investigated. T1 map acquisition was based on a snapshot-fast low-angle shot (FLASH) sequence. Lung function and blood gas tests were measured. The study documents reverse respiratory phase dependence of T1 measurements of the entire lung parenchyma in patients with emphysema and fibrosis. Furthermore, expiratory measurements showed higher and reverse differences between patient groups compared to inspiratory measurements. For the emphysema group, the average T1 value in inspiration was 1033 ± 74 ms. The average of the mean T1 values in expiration was 982 ± 56 ms. For the patients with fibrosis, the average T 1 value in inspiration was 996 ± 103 ms. Compared to that, the average T1 value in expiration was 1282 ± 170 ms. Linear regression of T1 vs. lung function parameters showed the highest regression coefficients for total lung capacity (TLC) and residual volume (RV) in expiration, the values were inversely proportionally dependent on the pooled expiratory T1 values. These findings underline the strong but nonuniform influence of the inspirational status during T1 measurements of the lung. T1 maps in both emphysema and fibrosis should preferably be acquired at expiration if reliable data are to be obtained.
Keyword Diffuse lung disease
Lung function
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Centre for Advanced Imaging Publications
 
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