T2-weighted 3D fMRI using S2-SSFP at 7 tesla

Barth, Markus, Meyer, Heiko, Kannengiesser, Stephan A. R., Polimeni, Jonathan R., Wald, Lawrence L. and Norris, David G. (2010) T2-weighted 3D fMRI using S2-SSFP at 7 tesla. Magnetic Resonance in Medicine, 63 4: 1015-1020. doi:10.1002/mrm.22283


Author Barth, Markus
Meyer, Heiko
Kannengiesser, Stephan A. R.
Polimeni, Jonathan R.
Wald, Lawrence L.
Norris, David G.
Title T2-weighted 3D fMRI using S2-SSFP at 7 tesla
Journal name Magnetic Resonance in Medicine   Check publisher's open access policy
ISSN 0740-3194
1522-2594
Publication date 2010-01-01
Year available 2010
Sub-type Article (original research)
DOI 10.1002/mrm.22283
Open Access Status DOI
Volume 63
Issue 4
Start page 1015
End page 1020
Total pages 6
Place of publication Hoboken, NJ United States
Publisher John Wiley and Sons, Inc.
Language eng
Subject 2741 Radiology Nuclear Medicine and imaging
2700 Medicine
Abstract In this study, the sensitivity of the S2-steady-state free precession (SSFP) signal for functional MRI at 7 T was investigated. In order to achieve the necessary temporal resolution, a three-dimensional acquisition scheme with acceleration along two spatial axes was employed. Activation maps based on S2-steady-state free precession data showed similar spatial localization of activation and sensitivity as spin-echo echo-planar imaging (SE-EPI), but data can be acquired with substantially lower power deposition. The functional sensitivity estimated by the average z-values was not significantly different for SE-EPI compared to the S2-signal but was slightly lower for the S2-signal (6.74 ± 0.32 for the TR = 15 ms protocol and 7.51 ± 0.78 for the TR = 27 ms protocol) compared to SE-EPI (7.49 ± 1.44 and 8.05 ± 1.67) using the same activated voxels, respectively. The relative signal changes in these voxels upon activation were slightly lower for SE-EPI (2.37% ± 0.18%) compared to the TR 5 15 ms S2-SSFP protocol (2.75% ± 0.53%) and significantly lower than the TR = 27 ms protocol (5.38% ± 1.28%), in line with simulations results. The large relative signal change for the long TR SSFP protocol can be explained by contributions from multiple coherence pathways and the low intrinsic intensity of the S2 signal. In conclusion, whole-brain T2-weighted functional MRI with negligible image distortion at 7 T is feasible using the S2-SSFP sequence and partially parallel imaging.
Keyword 7 tesla
BOLD
Brain
Neuroimaging
Steady-state free procession
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID NCRR P41RR14075
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Centre for Advanced Imaging Publications
 
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