Three dimensional echo-planar imaging at 7 Tesla

Poser, B. A., Koopmans, P. J., Witzel, T., Wald, L. L. and Barth, M. (2010) Three dimensional echo-planar imaging at 7 Tesla. NeuroImage, 51 1: 261-266. doi:10.1016/j.neuroimage.2010.01.108

Author Poser, B. A.
Koopmans, P. J.
Witzel, T.
Wald, L. L.
Barth, M.
Title Three dimensional echo-planar imaging at 7 Tesla
Journal name NeuroImage   Check publisher's open access policy
ISSN 1053-8119
Publication date 2010-01-01
Year available 2010
Sub-type Article (original research)
DOI 10.1016/j.neuroimage.2010.01.108
Open Access Status DOI
Volume 51
Issue 1
Start page 261
End page 266
Total pages 6
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Abstract Functional MRI (fMRI) most commonly employs 2D echo-planar imaging (EPI). The advantages for fMRI brought about by the increasingly popular ultra-high field strengths are best exploited in high-resolution acquisitions, but here 2D EPI becomes unpractical for several reasons, including the very long volume acquisitions times. In this study at 7 T, a 3D EPI sequence with full parallel and partial Fourier imaging capability along both phase encoding axes was implemented and used to evaluate the sensitivity of 3D and corresponding 2D EPI acquisitions at four different spatial resolutions ranging from small to typical voxel sizes (1.5-3.0mm isotropic). Whole-brain resting state measurements (N=4) revealed a better, or at least comparable sensitivity of the 3D method for gray and white matter. The larger vulnerability of 3D to physiological effects was outweighed by the much shorter volume TR, which moreover allows whole-brain coverage at high resolution within fully acceptable limits for event-related fMRI: TR was only 3.07s for 1.5mm, 1.88s for 2.0mm, 1.38s for 2.5mm and 1.07s for 3.0mm isotropic resolution. In order to investigate the ability to detect and spatially resolve BOLD activation in the visual cortex, functional 3D EPI experiments (N=8) were performed at 1mm isotropic resolution with parallel imaging acceleration of 3 3, resulting in a TR of only 3.2s for whole-brain coverage.From our results, and several other practical advantages of 3D over 2D EPI found in the present study, we conclude that 3D EPI provides a useful alternative for whole-brain fMRI at 7 T, not only when high-resolution data are required.
Keyword Neurosciences
Radiology, Nuclear Medicine & Medical Imaging
Neurosciences & Neurology
Radiology, Nuclear Medicine & Medical Imaging
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID NCRR P41RR14075
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Centre for Advanced Imaging Publications
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Citation counts: TR Web of Science Citation Count  Cited 100 times in Thomson Reuters Web of Science Article | Citations
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