Genome-wide meta-analysis identifies new susceptibility loci for migraine

Anttila, Verneri, Winsvold, Bendik S., Gormley, Padhraig, Kurth, tobias, Bettella, Francesco, McMahon, george, Kallela, mikko, Malik, Rainer, De Vries, Boukje, Terwindt, Gisela, Medland, Sarah E., Todt, Unda, McArdle, Wendy L., Quaye, Lydia, Koiranen, Markku, Ikram, M. Arfan, Lehtimaki, Terho, Stam, Anine H., Ligthart, Lannie, Wedenoja, Juho, Dunham, Ian, Neale, Benjamin M., Palta, Priit, Hamalainen, Eija, Schurks, Markus, Rose, Lynda M., Buring, Julie E., Ridker, Paul M., Steinberg, Stacy, Stefansson, Hreinn, Jakobsson, Finnbogi, Lawlor, Debbie A., Evans, David M., Ring, Susan M., Farkkila, Markus, Artto, Ville, Kaunisto, Mari A., Freilinger,Tobias, Schoenen, Jean, Frants, Rune R., Pelzer,Nadine, Weller, Claudia M., Zielman, Ronald, Heath, Andrew C., Madden, Pamela A. F., Montgomery, Grant W., Martin, Nicholas G., Borck, Guntram, Gobel, Hartmut, Heinze, Axel, Heinze-Kuhn, Katja, Williams, Frances M. K., Hartikainen, Anna-Liisa, Pouta, Anneli, Van Den Ende, Joyce, Uitterlinden, Andre G., Hofman, Albert, Amin, Najaf, Hottenga, Jouke-Jan, Vink, Jacqueline M., Heikkila, Kauko, Alexander, Michael, Muller-Myhsok, Bertram, Schreiber, Stefan, Meitinger, Thomas, Wichmann, Heinz .Erich, Aromaa, Arpo, Eriksson, Johan G., Traynor, Bryan J., Trabzuni, Daniah, Rossin, Elizabeth, Lage, Kasper, Jacobs, Suzanne B. R., Gibbs, J. Raphael, Birney, Ewan, Kaprio, Jaakko, Penninx, Brenda W., Boomsma, Dorret I., Van Duijn, Cornelia, Raitakari, Olli, Jarvelin, Marjo-Riitta, Zwart, John-Anker, Cherkas, Lynn, Strachan, David P., Kubisch, Christian, Ferrari, Michael D., Van Den Maagdenberg, Arn M. J. M., Dichgans, Martin, Wessman, Maija, Smith, George Davey, Stefansson, Kari, Daly, Mark J., Nyholt, Dale R., Chasman, Daniel I. and Palotie, Aarno (2013) Genome-wide meta-analysis identifies new susceptibility loci for migraine. Nature Genetics, 45 8: 912-917. doi:10.1038/ng.2676

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Author Anttila, Verneri
Winsvold, Bendik S.
Gormley, Padhraig
Kurth, tobias
Bettella, Francesco
McMahon, george
Kallela, mikko
Malik, Rainer
De Vries, Boukje
Terwindt, Gisela
Medland, Sarah E.
Todt, Unda
McArdle, Wendy L.
Quaye, Lydia
Koiranen, Markku
Ikram, M. Arfan
Lehtimaki, Terho
Stam, Anine H.
Ligthart, Lannie
Wedenoja, Juho
Dunham, Ian
Neale, Benjamin M.
Palta, Priit
Hamalainen, Eija
Schurks, Markus
Rose, Lynda M.
Buring, Julie E.
Ridker, Paul M.
Steinberg, Stacy
Stefansson, Hreinn
Jakobsson, Finnbogi
Lawlor, Debbie A.
Evans, David M.
Ring, Susan M.
Farkkila, Markus
Artto, Ville
Kaunisto, Mari A.
Freilinger,Tobias
Schoenen, Jean
Frants, Rune R.
Pelzer,Nadine
Weller, Claudia M.
Zielman, Ronald
Heath, Andrew C.
Madden, Pamela A. F.
Montgomery, Grant W.
Martin, Nicholas G.
Borck, Guntram
Gobel, Hartmut
Heinze, Axel
Heinze-Kuhn, Katja
Williams, Frances M. K.
Hartikainen, Anna-Liisa
Pouta, Anneli
Van Den Ende, Joyce
Uitterlinden, Andre G.
Hofman, Albert
Amin, Najaf
Hottenga, Jouke-Jan
Vink, Jacqueline M.
Heikkila, Kauko
Alexander, Michael
Muller-Myhsok, Bertram
Schreiber, Stefan
Meitinger, Thomas
Wichmann, Heinz .Erich
Aromaa, Arpo
Eriksson, Johan G.
Traynor, Bryan J.
Trabzuni, Daniah
Rossin, Elizabeth
Lage, Kasper
Jacobs, Suzanne B. R.
Gibbs, J. Raphael
Birney, Ewan
Kaprio, Jaakko
Penninx, Brenda W.
Boomsma, Dorret I.
Van Duijn, Cornelia
Raitakari, Olli
Jarvelin, Marjo-Riitta
Zwart, John-Anker
Cherkas, Lynn
Strachan, David P.
Kubisch, Christian
Ferrari, Michael D.
Van Den Maagdenberg, Arn M. J. M.
Dichgans, Martin
Wessman, Maija
Smith, George Davey
Stefansson, Kari
Daly, Mark J.
Nyholt, Dale R.
Chasman, Daniel I.
Palotie, Aarno
Title Genome-wide meta-analysis identifies new susceptibility loci for migraine
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1061-4036
1546-1718
Publication date 2013-01-01
Sub-type Article (original research)
DOI 10.1038/ng.2676
Open Access Status File (Author Post-print)
Volume 45
Issue 8
Start page 912
End page 917
Total pages 6
Place of publication New York, NY United States
Publisher Nature Publishing Group
Language eng
Subject 1311 Genetics
Abstract Migraine is the most common brain disorder, affecting approximately 14% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P < 5 × 10-8). Five loci are new: near AJAP1 at 1p36, near TSPAN2 at 1p13, within FHL5 at 6q16, within C7orf10 at 7p14 and near MMP16 at 8q21. Three of these loci were identified in disease subgroup analyses. Brain tissue expression quantitative trait locus analysis suggests potential functional candidate genes at four loci: APOA1BP, TBC1D7, FUT9, STAT6 and ATP5B.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
UQ Diamantina Institute Publications
 
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