A population-based study of genetic variation and psychotic experiences in adolescents

Zammit, Stanley, Hamshere, Marian, Dwyer, Sarah, Georgiva, Lyudmila, Timpson, Nic, Moskvina, Valentina, Richards, Alexander, Evans, David M., Lewis, Glyn, Jones, Peter, Owen, Michael J. and O'Donovan, Michael C. (2013) A population-based study of genetic variation and psychotic experiences in adolescents. Schizophrenia Bulletin, Advance Access 1-9. doi:10.1093/schbul/sbt146


Author Zammit, Stanley
Hamshere, Marian
Dwyer, Sarah
Georgiva, Lyudmila
Timpson, Nic
Moskvina, Valentina
Richards, Alexander
Evans, David M.
Lewis, Glyn
Jones, Peter
Owen, Michael J.
O'Donovan, Michael C.
Title A population-based study of genetic variation and psychotic experiences in adolescents
Journal name Schizophrenia Bulletin   Check publisher's open access policy
ISSN 0586-7614
1745-1701
Publication date 2013-10-30
Sub-type Article (original research)
DOI 10.1093/schbul/sbt146
Volume Advance Access
Start page 1
End page 9
Total pages 9
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Language eng
Formatted abstract
Psychotic experiences are not uncommon in general population samples, but no studies have examined to what extent confirmed risk variants for schizophrenia are associated with such experiences. A total of 3483 children in a birth cohort study participated in semistructured interviews for psychotic experiences at ages 12 and 18. We examined whether (1) a composite measure of risk for schizophrenia conferred by common alleles (polygenic score) was associated with psychotic experiences, (2) variants with genome-wide evidence for association with schizophrenia were associated with psychotic experiences, and (3) we could identify genetic variants for psychotic experiences using a genome-wide association (GWA) approach. We found no evidence that a schizophrenia polygenic score, or variants showing genome-wide evidence of association with schizophrenia, were associated with adolescent psychotic experiences within the general population. In fact, individuals who had a higher number of risk alleles for genome-wide hits for schizophrenia showed a decreased risk of psychotic experiences. In the GWA study, no variants showed GWA for psychotic experiences, and there was no evidence that the strongest hits (P < 5 × 10−5) were enriched for variants associated with schizophrenia in large consortia. Although polygenic scores are weak tools for prediction of schizophrenia, they show strong evidence of association with this disorder. Our findings, however, lend little support to the hypothesis that psychotic experiences in population-based samples of adolescents share a comparable genetic architecture to schizophrenia, or that utilizing a broader and more common phenotype of psychotic experiences will be an efficient approach to increase understanding of the genetic etiology of schizophrenia.
Keyword Psychosis
Schizophrenia
Epidemiology
ALSPAC
GWAS
Polygenic
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
UQ Diamantina Institute Publications
 
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Created: Thu, 20 Mar 2014, 01:57:02 EST by Kylie Hengst on behalf of UQ Diamantina Institute