Harnessing massively parallel sequencing in personalized head and neck oncology

Jessri, M. and Farah, C. S. (2014) Harnessing massively parallel sequencing in personalized head and neck oncology. Journal of Dental Research, 93 5: 437-444. doi:10.1177/0022034514524783


Author Jessri, M.
Farah, C. S.
Title Harnessing massively parallel sequencing in personalized head and neck oncology
Journal name Journal of Dental Research   Check publisher's open access policy
ISSN 0022-0345
1544-0591
Publication date 2014-05-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1177/0022034514524783
Volume 93
Issue 5
Start page 437
End page 444
Total pages 8
Place of publication Thousand Oaks, CA, United States
Publisher Sage Publications
Collection year 2015
Language eng
Formatted abstract
Advances in the management of patients with head and neck squamous cell carcinoma (HNSCC) have not significantly changed the prognosis of this tumor over the past five decades. Molecular heterogeneity of HNSCC and its association with HPV, in addition to the increase in the number of cancers arising in traditionally low-risk patients, are among some of the obstacles to the successful management of this group of tumors. Massively parallel sequencing, otherwise known as next-generation sequencing (NGS), is rapidly changing conventional patient management by providing detailed information about each patient’s genome and transcriptome. Despite major advances in technology and a significant reduction in the cost of sequencing, NGS remains mainly limited to research facilities. In addition, there are only a few published studies that have utilized this technology in HNSCC. This paper aims to report briefly on current commercially available NGS platforms and discuss their clinical applications, ethical considerations, and utilization in personalized patient care, particularly as this relates to head and neck cancer.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
Official 2015 Collection
School of Dentistry Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 3 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 6 times in Scopus Article | Citations
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Created: Wed, 19 Mar 2014, 20:04:10 EST by Roheen Gill on behalf of UQ Centre for Clinical Research