DISC1 Ser704Cys impacts thalamic-prefrontal connectivity

Liu, Bing, Fan, Lingzhong, Cui, Yue, Zhang, Xiaolong, Hou, Bing, Li, Yonghui, Qin, Wen, Wang, Dawei, Yu, Chunshui and Jiang, Tianzi (2013) DISC1 Ser704Cys impacts thalamic-prefrontal connectivity. Brain Structure and Function, 1-10. doi:10.1007/s00429-013-0640-5

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Author Liu, Bing
Fan, Lingzhong
Cui, Yue
Zhang, Xiaolong
Hou, Bing
Li, Yonghui
Qin, Wen
Wang, Dawei
Yu, Chunshui
Jiang, Tianzi
Title DISC1 Ser704Cys impacts thalamic-prefrontal connectivity
Formatted title
DISC1 Ser704Cys impacts thalamic-prefrontal connectivity
Journal name Brain Structure and Function   Check publisher's open access policy
ISSN 1863-2653
Publication date 2013-10-22
Year available 2013
Sub-type Article (original research)
DOI 10.1007/s00429-013-0640-5
Open Access Status DOI
Start page 1
End page 10
Total pages 10
Place of publication Heidelberg, Germany
Publisher Springer
Language eng
Formatted abstract
The Disrupted-in-Schizophrenia 1 (DISC1) gene has been thought as a putative susceptibility gene for various psychiatric disorders, and DISC1 Ser704Cys is associated with variations of brain morphology and function. Moreover, our recent diffusion magnetic resonance imaging (dMRI) study reported that DISC1 Ser704Cys was associated with information transfer efficiency in the brain anatomical network. However, the effects of the DISC1 gene on functional brain connectivity and networks, especially for thalamic-prefrontal circuit, which are disrupted in various psychiatric disorders, are largely unknown. Using a functional connectivity density (FCD) mapping method based on functional magnetic resonance imaging data in a large sample of healthy Han Chinese subjects, we first investigated the association between DISC1 Ser704Cys and short- and long-range FCD hubs. Compared with Ser homozygotes, Cys-allele individuals had increased long-range FCD hubs in the bilateral thalami. The functional and anatomical connectivity of the thalamus to the prefrontal cortex was further analyzed. Significantly increased thalamic-prefrontal functional connectivity and decreased thalamic-prefrontal anatomical connectivity were found in DISC1 Cys-allele carriers. Our findings provide consistent evidence that the DISC1 Ser704Cys polymorphism influences the thalamic-prefrontal circuits in humans and may provide new insights into the neural mechanisms that link DISC1 and the risk for psychiatric disorders.
Keyword DISC1
Functional connectivity density
Anatomical connectivity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online 22 October 2013

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2014 Collection
Centre for Advanced Imaging Publications
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Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 19 Mar 2014, 01:55:34 EST by Debra McMurtrie on behalf of Queensland Brain Institute