Effect of vitamin D supplementation on antibiotic use: a randomized controlled trial

Tran, Bich, Armstrong, Bruce K., Ebeling, Peter R., English, Dallas R., Kimlin, Michael G., Van Der Pols, Jolieke C., Venn, Alison, Gebski, Val, Whiteman, David C., Webb, Penelope M. and Neale, Rachel E. (2014) Effect of vitamin D supplementation on antibiotic use: a randomized controlled trial. American Journal of Clinical Nutrition, 99 1: 156-161. doi:10.3945/ajcn.113.063271

Author Tran, Bich
Armstrong, Bruce K.
Ebeling, Peter R.
English, Dallas R.
Kimlin, Michael G.
Van Der Pols, Jolieke C.
Venn, Alison
Gebski, Val
Whiteman, David C.
Webb, Penelope M.
Neale, Rachel E.
Title Effect of vitamin D supplementation on antibiotic use: a randomized controlled trial
Journal name American Journal of Clinical Nutrition   Check publisher's open access policy
ISSN 0002-9165
Publication date 2014-01-01
Year available 2013
Sub-type Article (original research)
DOI 10.3945/ajcn.113.063271
Open Access Status Not Open Access
Volume 99
Issue 1
Start page 156
End page 161
Total pages 6
Place of publication Bethesda, MD, United States
Publisher American Society for Nutrition
Language eng
Formatted abstract
Background: Observational data suggested that supplementation with vitamin D could reduce risk of infection, but trial data are inconsistent.
We aimed to examine the effect of oral vitamin D supplementation on antibiotic use.
We conducted a post hoc analysis of data from pilot D-Health, which is a randomized trial carried out in a general community setting between October 2010 and February 2012. A total of 644 Australian residents aged 60-84 y were randomly assigned to receive monthly doses of a placebo (n = 214) or 30,000 (n = 215) or 60,000 (n = 215) IU oral cholecalciferol for ≤12 mo. Antibiotics prescribed during the intervention period were ascertained by linkage with pharmacy records through the national health insurance scheme (Medicare Australia).
People who were randomly assigned 60,000 IU cholecalciferol had nonsignificant 28% lower risk of having antibiotics prescribed at least once than did people in the placebo group (RR: 0.72; 95% CI: 0.48, 1.07). In analyses stratified by age, in subjects aged ≥70 y, there was a significant reduction in antibiotic use in the high-dose vitamin D compared with placebo groups (RR: 0.53; 95% CI: 0.32, 0.90), whereas there was no effect in participants aged <70 y (RR: 1.07; 95% CI: 0.58, 1.97) (P-interaction = 0.1).
Although this study was a post hoc analysis and statistically nonsignificant, this trial lends some support to the hypothesis that supplementation with 60,000 IU vitamin D/mo is associated with lower risk of infection, particularly in older adults. The trial was registered at the Australian New Zealand Clinical Trials Registry (anzctr.org.au) as ACTRN12609001063202.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online 9 October 2013

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
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Created: Tue, 18 Mar 2014, 23:14:06 EST by Nyree Divitini on behalf of School of Public Health