Prevalence of osteoporosis in prostate cancer survivors: a meta-analysis

Lassemillante, Annie-Claude M., Doi, Suhail A. R, Hooper, John D., Prins, John B. and Wright, Olivia R. L. (2014) Prevalence of osteoporosis in prostate cancer survivors: a meta-analysis. Endocrine, 45 3: 370-381. doi:10.1007/s12020-013-0083-z

Author Lassemillante, Annie-Claude M.
Doi, Suhail A. R
Hooper, John D.
Prins, John B.
Wright, Olivia R. L.
Title Prevalence of osteoporosis in prostate cancer survivors: a meta-analysis
Journal name Endocrine   Check publisher's open access policy
ISSN 1355-008X
Publication date 2014-04-01
Year available 2013
Sub-type Article (original research)
DOI 10.1007/s12020-013-0083-z
Open Access Status Not yet assessed
Volume 45
Issue 3
Start page 370
End page 381
Total pages 12
Place of publication Totowa, NJ, United States
Publisher Humana Press
Language eng
Abstract Androgen deprivation therapy (ADT), which is used in the treatment of prostate cancer (PCa), is associated with increased morbidity. Severe bone loss is a major consequence of androgen ablation and with an increasing number of patients undergoing this treatment, the incidence of osteoporosis and fractures can be expected to increase with a significant impact on healthcare. To evaluate the prevalence of osteoporosis, we conducted a review of the literature on bone health in men with PCa undergoing ADT. A meta-analysis was conducted using the quality effects model, and sources of heterogeneity were further explored by consideration of discordant effect sizes of included studies in the meta-analysis and examining reasons thereof. Our analyses indicate that the prevalence of osteoporosis varies between 9 and 53 % with this variation partially explained by treatment duration, disease stage, ethnicity and site of osteoporosis measurement. While it is well known that a rapid decline in bone health amongst men with PCa on ADT occurs, this meta-analysis documents the high prevalence of osteoporosis in this population and reinforces the need of preventative approaches as part of usual care of PCa patients.
Keyword Androgen-Deprivation Therapy
Bone-Mineral Density
Fracture Risk
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online ahead of print 31 October 2013

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Created: Tue, 18 Mar 2014, 22:45:26 EST by Nyree Divitini on behalf of Health LinQ