Cigarette smoking and pancreatic cancer risk: more to the story than just pack-years

Schulte, Annaka, Pandeya, Nirmala, Tran, Bich, Fawcett, Jonathan, Fritschi, Lin, Risch, Harvey A., Webb, Penelope M., Whiteman, David C., Neale, Rachel E. and for the Queensland Pancreatic Cancer Study Group (2014) Cigarette smoking and pancreatic cancer risk: more to the story than just pack-years. European Journal of Cancer, 50 5: 997-1003. doi:10.1016/j.ejca.2013.12.014

Author Schulte, Annaka
Pandeya, Nirmala
Tran, Bich
Fawcett, Jonathan
Fritschi, Lin
Risch, Harvey A.
Webb, Penelope M.
Whiteman, David C.
Neale, Rachel E.
for the Queensland Pancreatic Cancer Study Group
Title Cigarette smoking and pancreatic cancer risk: more to the story than just pack-years
Journal name European Journal of Cancer   Check publisher's open access policy
ISSN 0959-8049
Publication date 2014-03-01
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.ejca.2013.12.014
Open Access Status Not Open Access
Volume 50
Issue 5
Start page 997
End page 1003
Total pages 7
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon Press
Language eng
Subject 1306 Cancer Research
2730 Oncology
Formatted abstract
Purpose Cigarette smoking is an established risk factor for pancreatic adenocarcinoma. However, few studies have thoroughly investigated the effects of independent smoking dimensions (duration, intensity, cumulative dose and time since quitting) on risk estimates. We analysed data from the Queensland Pancreatic Cancer Study (QPCS), an Australian population-based case-control study, with the aim of determining which smoking component is primarily important to pancreatic cancer risk. Methods Our study included 705 pancreatic cancer patients and 711 controls. Logistic regression and generalised additive logistic regression (for non-linear dose effects) were used to determine odds ratios (ORs) and 95% confidence intervals (CIs). Results Compared to never-smokers, current smokers had an increased risk of pancreatic cancer (OR = 3.4; 95% CI 2.4-5.0) after adjustment for age, sex, education, alcohol intake and birth country. Of the various smoking dimensions, smoking duration and time since quitting had a greater effect on OR estimates (OR 1.3; 95% CI 1.1-1.4 and OR 0.8; 95% CI 0.7-0.8) than smoking intensity (OR 1.1; 95% CI 0.9-1.2), once ever-smoking was accounted for. Conclusions This study confirms the association between cigarette smoking and pancreatic adenocarcinoma, and provides evidence to suggest that smoking pattern, in addition to dose effect, may affect disease risk.
Keyword Pancreatic neoplasms
Risk factors
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Public Health Publications
School of Medicine Publications
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