Augmenting melodic intonation therapy with non-invasive brain stimulation to treat impaired left-hemisphere function: two case studies

Al-Janabi, Shahd, Nickels, Lyndsey A., Sowman, Paul F., Burianova, Hana, Merrett, Dawn L. and Thompson, William F. (2014) Augmenting melodic intonation therapy with non-invasive brain stimulation to treat impaired left-hemisphere function: two case studies. Frontiers in Psychology, 5 FEB: 37.1-37.12. doi:10.3389/fpsyg.2014.00037

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Author Al-Janabi, Shahd
Nickels, Lyndsey A.
Sowman, Paul F.
Burianova, Hana
Merrett, Dawn L.
Thompson, William F.
Title Augmenting melodic intonation therapy with non-invasive brain stimulation to treat impaired left-hemisphere function: two case studies
Journal name Frontiers in Psychology   Check publisher's open access policy
ISSN 1664-1078
Publication date 2014-02-01
Year available 2014
Sub-type Article (original research)
DOI 10.3389/fpsyg.2014.00037
Open Access Status DOI
Volume 5
Issue FEB
Start page 37.1
End page 37.12
Total pages 12
Place of publication Lausanne, Switzerland
Publisher Frontiers Research Foundation
Language eng
Abstract The purpose of this study was to investigate whether or not the right hemisphere can be engaged using Melodic Intonation Therapy (MIT) and excitatory repetitive transcranial magnetic stimulation (rTMS) to improve language function in people with aphasia. The two participants in this study (GOE and AMC) have chronic non-fluent aphasia. A functional Magnetic Resonance Imaging (fMRI) task was used to localize the right Broca's homolog area in the inferior frontal gyrus for rTMS coil placement. The treatment protocol included an rTMS phase, which consisted of 3 treatment sessions that used an excitatory stimulation method known as intermittent theta burst stimulation, and a sham-rTMS phase, which consisted of 3 treatment sessions that used a sham coil. Each treatment session was followed by 40 min of MIT. A linguistic battery was administered after each session. Our findings show that one participant, GOE, improved in verbal fluency and the repetition of phrases when treated with MIT in combination with TMS. However, AMC showed no evidence of behavioral benefit from this brief treatment trial. Post-treatment neural activity changes were observed for both participants in the left Broca's area and right Broca's homolog. These case studies indicate that a combination of MIT and rTMS applied to the right Broca's homolog and MIT has the potential to improve speech and language outcomes for at least some people with post-stroke aphasia.
Keyword aphasia
stroke
fMRI
rTMS
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
Centre for Advanced Imaging Publications
 
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