The signal pathways in azoxymethane-induced colon cancer and preventive implications

Chen, Jiezhong and Huang, Xu-Feng (2009) The signal pathways in azoxymethane-induced colon cancer and preventive implications. Cancer Biology and Therapy, 8 14: 1313-1317. doi:10.4161/cbt.8.14.8983


Author Chen, Jiezhong
Huang, Xu-Feng
Title The signal pathways in azoxymethane-induced colon cancer and preventive implications
Journal name Cancer Biology and Therapy   Check publisher's open access policy
ISSN 1538-4047
1555-8576
Publication date 2009-07-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.4161/cbt.8.14.8983
Open Access Status Not Open Access
Volume 8
Issue 14
Start page 1313
End page 1317
Total pages 5
Place of publication Austin, TX, United States
Publisher Landes Bioscience
Language eng
Formatted abstract
Colon cancer is the third most common cancer and third most common cause of cancer-related death in the USA according to 2008 American Cancer Society statistics. The carcinogenesis of colon cancer has been associated with both genetics and environmental factors. It has been found that several signal pathways, including K-ras, Src/PI3K/Akt, β-catenin, TGFβ and p53 play critical roles in its pathogenesis. The 5 y survival rate of metastatic colon cancer is below 10%. Thus, it is necessary to further understand its biology and search for effective therapy. Azoxymethane (AOM) is a common model for colon cancer. It can specifically induce colon cancer similar to the pathogenesis of human sporadic colon cancer. Thus, it has been extensively used in the study of the molecular biology, prevention and treatment of colon cancer. After administration, AOM is metabolised into methylazoxymethanol by CYP2E1, which causes DNA mutations. Mutation of K-ras activates this pathway and its downstream PI3K/Akt pathway and MAPK pathway. Mutation of β-catenin leads to cell proliferation. TGFβ, a pro-apoptotic protein, is inhibited. All of these changes form the basis of AOM carcinogenesis. This model has been used in the study of the genetic deficiencies of colon cancer and in the prevention and treatment of the disease. For example, TGF-β R2 and adiponectin knockout mice are more susceptible to AOM, while high amylose cornstarch, green tea and artemisia have protective effects.
Keyword Azoxymethane
Colon cancer
Signal pathways
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Biomedical Sciences Publications
 
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Created: Thu, 13 Mar 2014, 23:51:18 EST by Jiezhong Chen on behalf of School of Biomedical Sciences