Genome-wide association study identifies four loci associated with eruption of permanent teeth

Geller, Frank, Feenstra, Bjarke, Zhang, Hao, Shaffer, John R., Hansen, Thomas, Esserlind, Ann-Louise, Boyd, Heather A., Nohr, Ellen A., Timpson, Nicholas J., Fatemifar, Ghazaleh, Paternoster, Lavinia, Evans, David M., Weyant, Robert J., Levy, Steven M., Lathrop, Mark, Smith, George Davey, Murray, Jeffrey C., Olesen, Jes, Werge, Thomas, Marazita, Mary L., Sorensen, Thorkild I. A. and Melbye, Mads (2011) Genome-wide association study identifies four loci associated with eruption of permanent teeth. PLoS Genetics, 7 9: e1002275.1-e1002275.9. doi:10.1371/journal.pgen.1002275

Author Geller, Frank
Feenstra, Bjarke
Zhang, Hao
Shaffer, John R.
Hansen, Thomas
Esserlind, Ann-Louise
Boyd, Heather A.
Nohr, Ellen A.
Timpson, Nicholas J.
Fatemifar, Ghazaleh
Paternoster, Lavinia
Evans, David M.
Weyant, Robert J.
Levy, Steven M.
Lathrop, Mark
Smith, George Davey
Murray, Jeffrey C.
Olesen, Jes
Werge, Thomas
Marazita, Mary L.
Sorensen, Thorkild I. A.
Melbye, Mads
Title Genome-wide association study identifies four loci associated with eruption of permanent teeth
Journal name PLoS Genetics   Check publisher's open access policy
ISSN 1553-7390
Publication date 2011-01-01
Year available 2011
Sub-type Article (original research)
DOI 10.1371/journal.pgen.1002275
Open Access Status DOI
Volume 7
Issue 9
Start page e1002275.1
End page e1002275.9
Total pages 9
Place of publication San Francisco, CA, United States
Publisher Public Library of Science
Language eng
Abstract The sequence and timing of permanent tooth eruption is thought to be highly heritable and can have important implications for the risk of malocclusion, crowding, and periodontal disease. We conducted a genome-wide association study of number of permanent teeth erupted between age 6 and 14 years, analyzed as age-adjusted standard deviation score averaged over multiple time points, based on childhood records for 5,104 women from the Danish National Birth Cohort. Four loci showed association at P<5×10-8 and were replicated in four independent study groups from the United States and Denmark with a total of 3,762 individuals; all combined P-values were below 10-11. Two loci agreed with previous findings in primary tooth eruption and were also known to influence height and breast cancer, respectively. The two other loci pointed to genomic regions without any previous significant genome-wide association study results. The intronic SNP rs7924176 in ADK could be linked to gene expression in monocytes. The combined effect of the four genetic variants was most pronounced between age 10 and 12 years, where children with 6 to 8 delayed tooth eruption alleles had on average 3.5 (95% confidence interval: 2.9-4.1) fewer permanent teeth than children with 0 or 1 of these alleles.
Keyword Genetics & Heredity
Genetics & Heredity
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID R19-A2059
R01-DE 014899
WT 084762MA
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
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