Adult height variants affect birth length and growth rate in children

Paternoster, Lavinia, Howe, Laura D., Tilling, Kate, Weedon, Michael N., Freathy, Rachel M., Frayling, Timothy M., Kemp, John P., Smith, George Davey, Timpson, Nicholas J., Ring, Susan M., Evans, David M. and Lawlor, Debbie A. (2011) Adult height variants affect birth length and growth rate in children. Human Molecular Genetics, 20 20: 4069-4075. doi:10.1093/hmg/ddr309

Author Paternoster, Lavinia
Howe, Laura D.
Tilling, Kate
Weedon, Michael N.
Freathy, Rachel M.
Frayling, Timothy M.
Kemp, John P.
Smith, George Davey
Timpson, Nicholas J.
Ring, Susan M.
Evans, David M.
Lawlor, Debbie A.
Title Adult height variants affect birth length and growth rate in children
Journal name Human Molecular Genetics   Check publisher's open access policy
ISSN 0964-6906
Publication date 2011-01-01
Year available 2011
Sub-type Article (original research)
DOI 10.1093/hmg/ddr309
Open Access Status Not yet assessed
Volume 20
Issue 20
Start page 4069
End page 4075
Total pages 7
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Language eng
Subject 1311 Genetics
2716 Genetics (clinical)
1312 Molecular Biology
Abstract Previous studies identified 180 single nucleotide polymorphisms (SNPs) associated with adult height, explaining ~10% of the variance. The age at which these begin to affect growth is unclear. We modelled the effect of these SNPs on birth length and childhood growth. A total of 7768 participants in the Avon Longitudinal Study of Parents and Children had data available. Individual growth trajectories from 0 to 10 years were estimated using mixed-effects linear spline models and differences in trajectories by individual SNPs and allelic score were determined. The allelic score was associated with birth length (0.026 cm increase per 'tall' allele, SE = 0.003, P = 1 × 10 -15, equivalent to 0.017 SD). There was little evidence of association between the allelic score and early infancy growth (0-3 months), but there was evidence of association between the allelic score and later growth. This association became stronger with each consecutive growth period, per 'tall' allele per month effects were 0.015 SD (3 months-1 year, SE 5 0.004), 0.023 SD (1-3 years, SE = 0.003) and 0.028 SD (3-10 years, SE = 0.003). By age 10, the mean height difference between individuals with ≤170 versus ≥191 'tall' alleles (the top and bottom 10%) was 4.7 cm (0.8 SD), explaining ~5% of the variance. There was evidence of associations with specific growth periods for some SNPs (rs3791675, EFEMP1 and rs6569648, L3MBTL3) and supportive evidence for previously reported age-dependent effects of HHIP and SOCS2 SNPs. SNPs associated with adult height influence birth length and have an increasing effect on growth from late infancy through to late childhood. By age 10, they explain half the height variance (~5%) of that explained in adults (~10%).
Keyword Biochemistry & Molecular Biology
Genetics & Heredity
Biochemistry & Molecular Biology
Genetics & Heredity
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID G0800582
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
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