Prospects and pitfalls in whole genome association studies

Lawrence R.W., Evans D.M. and Cardon L.R. (2005). Prospects and pitfalls in whole genome association studies. In: Meeting on Genetic Variation and Human Health, London England, (1589-1595). Jan, 2005. doi:10.1098/rstb.2005.1689

Author Lawrence R.W.
Evans D.M.
Cardon L.R.
Title of paper Prospects and pitfalls in whole genome association studies
Conference name Meeting on Genetic Variation and Human Health
Conference location London England
Conference dates Jan, 2005
Journal name Philosophical Transactions of the Royal Society B: Biological Sciences   Check publisher's open access policy
Place of Publication LONDON
Publication Year 2005
Year available 2005
Sub-type Fully published paper
DOI 10.1098/rstb.2005.1689
Open Access Status Not yet assessed
ISSN 0962-8436
Volume 360
Issue 1460
Start page 1589
End page 1595
Total pages 7
Language eng
Abstract/Summary Recent large-scale studies of common genetic variation throughout the human genome are making it feasible to conduct whole genome studies of genotype-phenotype associations. Such studies have the potential to uncover novel contributors to common complex traits and thus lead to insights into the aetiology of multifactorial phenotypes. Despite this promise, it is important to recognize that the availability of genetic markers and the ability to assay them at realistic cost does not guarantee success of this approach. There are a number of practical issues that require close attention, some forms of allelic architecture are not readily amenable to the association approach with even the most rigorous design, and doubtless new hurdles will emerge as the studies begin. Here we discuss the promise and current challenges of the whole genome approach, and raise some issues to consider in interpreting the results of the first whole genome studies.
Subjects 1100 Agricultural and Biological Sciences
1101 Medical Biochemistry and Metabolomics
Keyword Complex trait
Genetic association
Whole genome association
Q-Index Code E1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Conference Paper
Sub-type: Fully published paper
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