Genetic variants in the vitamin D receptor are associated with advanced prostate cancer at diagnosis: Findings from the prostate testing for cancer and treatment study and a systematic review

Chen, Lina, Smith, George Davey, Evans, David M., Cox, Angela, Lawlor, Debbie A., Donovan, Jenny, Yuan, Wei, Day, Ian N. M., Martin, Richard M., Lane, Athene, Rodriguez, Santi, Davis, Michael, Zuccolo, Luisa, Collin, Simon M., Hamdy, Freddie, Neal, David and Lewis, Sarah J. (2009) Genetic variants in the vitamin D receptor are associated with advanced prostate cancer at diagnosis: Findings from the prostate testing for cancer and treatment study and a systematic review. Cancer Epidemiology Biomarkers and Prevention, 18 11: 2874-2881. doi:10.1158/1055-9965.EPI-09-0544


Author Chen, Lina
Smith, George Davey
Evans, David M.
Cox, Angela
Lawlor, Debbie A.
Donovan, Jenny
Yuan, Wei
Day, Ian N. M.
Martin, Richard M.
Lane, Athene
Rodriguez, Santi
Davis, Michael
Zuccolo, Luisa
Collin, Simon M.
Hamdy, Freddie
Neal, David
Lewis, Sarah J.
Title Genetic variants in the vitamin D receptor are associated with advanced prostate cancer at diagnosis: Findings from the prostate testing for cancer and treatment study and a systematic review
Journal name Cancer Epidemiology Biomarkers and Prevention   Check publisher's open access policy
ISSN 1055-9965
1538-7755
Publication date 2009-01-01
Year available 2009
Sub-type Article (original research)
DOI 10.1158/1055-9965.EPI-09-0544
Open Access Status Not yet assessed
Volume 18
Issue 11
Start page 2874
End page 2881
Total pages 8
Place of publication Philadelphia, PA, United States
Publisher American Association for Cancer Research
Language eng
Abstract Low levels of plasma vitamin D have been implicated as a possible risk factor for both prostate cancer incidence and advanced disease, and recent phase II trials suggest that vitamin D supplementation might delay progression of prostate cancer. Common polymorphisms in the vitamin D receptor (VDR) are associated with VDR activity and are therefore potentially useful proxies for assessing whether vitamin D is causally related to advanced prostate cancer. We genotyped five well-known VDR polymorphisms in 1,604 men with prostate cancer from the Prostate Testing for Cancer and Treatment study. Our aim was to examine the association between VDR polymorphisms and cancer stage (localized versus advanced) as well as cancer grade (Gleason score <7 versus ≥7). Moreover, we also carried out a systematic review and meta-analysis of 13 similar studies. As a result of our meta-analysis, we revealed three polymorphisms, BsmI, ApaI, and TaqI, associated with high Gleason score with an overall summary odds ratios (95% confidence intervals) of 1.12 (1.00-1.25; bb versus BB + Bb), 1.25 (1.02-1.53; aa versus AA + Aa), and 0.82 (0.69-0.98; Tt + tt versus TT), respectively. The haplotype analysis revealed that the BsmI (B)-ApaI (A)-TaqI (t) participants compared with BsmI (b)-ApaI (a)-TaqI (T) individuals were less likely to have high Gleason scores (odds ratio, 0.84; 95% confidence interval, 0.71-1.00; Punadjusted = 0.050; Padjusted = 0.014). Our finding provides some support for the hypothesis that low levels of vitamin D may increase the risk of prostate cancer progression. Copyright
Keyword Oncology
Public, Environmental & Occupational Health
Oncology
Public, Environmental & Occupational Health
ONCOLOGY
PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH, SCI
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 96/20/06
C18281/A7062
2006/15
W81XWH-04-1-0280
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
 
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