A note on the power to detect transmission distortion in parent-child trios via the transmission disequilibrium test.

Evans D.M., Morris A.P., Cardon L.R. and Sham P.C. (2006) A note on the power to detect transmission distortion in parent-child trios via the transmission disequilibrium test.. Behavior genetics, 36 6: 947-950. doi:10.1007/s10519-006-9087-2


Author Evans D.M.
Morris A.P.
Cardon L.R.
Sham P.C.
Title A note on the power to detect transmission distortion in parent-child trios via the transmission disequilibrium test.
Journal name Behavior genetics   Check publisher's open access policy
ISSN 0001-8244
Publication date 2006-01-01
Year available 2006
Sub-type Article (original research)
DOI 10.1007/s10519-006-9087-2
Open Access Status Not yet assessed
Volume 36
Issue 6
Start page 947
End page 950
Total pages 4
Place of publication NEW YORK
Publisher SPRINGER
Language eng
Subject 1311 Genetics
2716 Genetics (clinical)
2802 Behavioral Neuroscience
3200 Psychology
Abstract Transmission distortion refers to deviation from the normal 50: 50 transmission of alleles from parents to offspring. Identification of genomic regions which undergo distortion is necessary for the correct interpretation of linkage and association studies, since tests of linkage using affected relative pairs and family based tests of association will yield spurious results in the presence of transmission distortion. With the increasing availability of genome-wide high density SNP data ( e. g. from the International HapMap project), identification of these loci is now a real possibility. Here we present an analytical formula which demonstrates that the power to detect transmission distortion is a simple function of the number of heterozygous parents in the sample and the level of distortion at the locus. Our results indicate that whilst it will be possible to identify loci undergoing major levels of distortion using tens or hundreds of trios, large sample sizes in the order of tens of thousands of trios will be necessary to detect minor levels of distortion with appreciable power. The corollary is that genome-wide searches are unlikely to identify loci where the level of distortion is small, although they may serve to identify interesting regions worthy of follow up.
Keyword Behavioral Sciences
Genetics & Heredity
Psychology, Multidisciplinary
Behavioral Sciences
Genetics & Heredity
Psychology
BEHAVIORAL SCIENCES
GENETICS & HEREDITY
PSYCHOLOGY, MULTIDISCIPLINARY
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID EY-126562
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: ResearcherID Downloads - Archived
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 7 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 13 Mar 2014, 20:08:48 EST by System User