The ATXN1 and TRIM31 genes are related to intelligence in an ADHD background: evidence from a large collaborative study totaling 4,963 subjects

Rizzi, Thais S., Arias-Vasquez, Alejandro, Rommelse, Nanda, Kuntsi, Jonna, Anney, Richard, Asherson, Philip, Buitelaar, Jan, Banaschewski, Tobias, Ebstein, Richard, Ruano, Dina, van der Sluis, Sophie, Markunas, Christina A., Garrett, Melanie E., Ashley-Koch, Allison E., Kollins, Scott H., Anastopoulos, Arthur D., Hansell, Narelle K., Wright, Margaret J., Montgomery, Grant W., Martin, Nicholas G., Harris, Sarah E., Davies, Gail, Tenesa, Albert, Porteous, David J., Starr, John M., Deary, Ian J., St. Pourcain, Beate, Smith, George Davey, Timpson, Nicholas J., Evans, David M., Gill, Michael, Miranda, Ana, Mulas, Fernando, Oades, Robert D., Roeyers, Herbert, Rothenberger, Aribert, Sergeant, Joseph, Sonuga-Barke, Edmund, Steinhausen, Hans Christoph, Taylor, Eric, Faraone, Stephen V., Franke, Barbara and Posthuma, Danielle (2011) The ATXN1 and TRIM31 genes are related to intelligence in an ADHD background: evidence from a large collaborative study totaling 4,963 subjects. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 156 2: 145-157. doi:10.1002/ajmg.b.31149

Author Rizzi, Thais S.
Arias-Vasquez, Alejandro
Rommelse, Nanda
Kuntsi, Jonna
Anney, Richard
Asherson, Philip
Buitelaar, Jan
Banaschewski, Tobias
Ebstein, Richard
Ruano, Dina
van der Sluis, Sophie
Markunas, Christina A.
Garrett, Melanie E.
Ashley-Koch, Allison E.
Kollins, Scott H.
Anastopoulos, Arthur D.
Hansell, Narelle K.
Wright, Margaret J.
Montgomery, Grant W.
Martin, Nicholas G.
Harris, Sarah E.
Davies, Gail
Tenesa, Albert
Porteous, David J.
Starr, John M.
Deary, Ian J.
St. Pourcain, Beate
Smith, George Davey
Timpson, Nicholas J.
Evans, David M.
Gill, Michael
Miranda, Ana
Mulas, Fernando
Oades, Robert D.
Roeyers, Herbert
Rothenberger, Aribert
Sergeant, Joseph
Sonuga-Barke, Edmund
Steinhausen, Hans Christoph
Taylor, Eric
Faraone, Stephen V.
Franke, Barbara
Posthuma, Danielle
Title The ATXN1 and TRIM31 genes are related to intelligence in an ADHD background: evidence from a large collaborative study totaling 4,963 subjects
Journal name American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics   Check publisher's open access policy
ISSN 1552-4841
Publication date 2011-01-01
Year available 2011
Sub-type Article (original research)
DOI 10.1002/ajmg.b.31149
Open Access Status Not yet assessed
Volume 156
Issue 2
Start page 145
End page 157
Total pages 13
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Abstract Intelligence is a highly heritable trait for which it has proven difficult to identify the actual genes. In the past decade, five whole-genome linkage scans have suggested genomic regions important to human intelligence; however, so far none of the responsible genes or variants in those regions have been identified. Apart from these regions, a handful of candidate genes have been identified, although most of these are in need of replication. The recent growth in publicly available data sets that contain both whole genome association data and a wealth of phenotypic data, serves as an excellent resource for fine mapping and candidate gene replication. We used the publicly available data of 947 families participating in the International Multi-Centre ADHD Genetics (IMAGE) study to conduct an in silico fine mapping study of previously associated genomic locations, and to attempt replication of previously reported candidate genes for intelligence. Although this sample was ascertained for attention deficit/hyperactivity disorder (ADHD), intelligence quotient (IQ) scores were distributed normally. We tested 667 single nucleotide polymorphisms (SNPs) within 15 previously reported candidate genes for intelligence and 29451 SNPs in five genomic loci previously identified through whole genome linkage and association analyses. Significant SNPs were tested in four independent samples (4,357 subjects), one ascertained for ADHD, and three population-based samples. Associations between intelligence and SNPs in the ATXN1 and TRIM31 genes and in three genomic locations showed replicated association, but only in the samples ascertained for ADHD, suggesting that these genetic variants become particularly relevant to IQ on the background of a psychiatric disorder.
Keyword ADHD
Candidate genes
Genetic association
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID R01MH081803
NWO 480-05-003
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
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