A haplotype map of the human genome

Belmont J.W., Boudreau A., Leal S.M., Hardenbol P., Pasternak S., Wheeler D.A., Willis T.D., Yu F., Yang H., Gao Y., Hu H., Hu W., Li C., Lin W., Liu S., Pan H., Tang X., Wang J., Wang W., Yu J., Zhang B., Zhang Q., Zhao H., Zhou J., Barry R., Blumenstiel B., Camargo A., Defelice M., Faggart M., Goyette M., Gupta S., Moore J., Nguyen H., Parkin M., Roy J., Stahl E., Winchester E., Altshuler D., Shen Y., Yao Z., Huang W., Chu X., He Y., Jin L., Liu Y., Shen Y., Sun W., Wang H., Wang Y., Wang Y., Xiong X., Xu L., Waye M.M.Y., Tsui S.K.W., Xue H., Wong J.T.-F., Galver L.M., Fan J.-B., Murray S.S., Oliphant A.R., Chee M.S., Montpetit A., Chagnon F., Ferretti V., Leboeuf M., Olivier J.-F., Phillips M.S., Roumy S., Sallee C., Verner A., Hudson T.J., Frazer K.A., Ballinger D.G., Cox D.R., Hinds D.A., Stuve L.L., Kwok P.-Y., Cai D., Koboldt D.C., Miller R.D., Pawlikowska L., Taillon-Miller P., Xiao M., Tsui L.-C., Mak W., Sham P.C., Song Y.Q., Tam P.K.H., Nakamura Y., Kawaguchi T., Kitamoto T., Morizono T., Nagashima A., Ohnishi Y., Sekine A., Tanaka T., Deloukas P., Bird C.P., Delgado M., Dermitzakis E.T., Gwilliam R., Hunt S., Morrison J., Powell D., Stranger B.E., Whittaker P., Bentley D.R., De Bakker P.I.W., Barrett J., Fry B., Maller J., McCarroll S., Patterson N., Pe'er I., Purcell S., Richter D.J., Sabeti P., Saxena R., Schaffner S.F., Varilly P., Stein L.D., Krishnan L., Smith A.V., Thorisson G.A., Chakravarti A., Chen P.E., Cutler D.J., Kashuk C.S., Lin S., Abecasis G.R., Guan W., Munro H.M., Qin Z.S., Thomas D.J., McVean G., Bottolo L., Eyheramendy S., Freeman C., Marchini J., Myers S., Spencer C., Stephens M., Donnelly P., Cardon L.R., Clarke G., Evans D.M., Morris A.P., Weir B.S., Tsunoda T., Mullikin J.C., Sherry S.T., Feolo M., Zhang H., Zeng C., Zhao H., Matsuda I., Fukushima Y., Macer D.R., Suda E., Rotimi C.N., Adebamowo C.A., Ajayi I., Aniagwu T., Marshall P.A., Nkwodimmah C., Royal C.D.M., Leppert M.F., Dixon M., Peiffer A., Qiu R., Kent A., Kato K., Niikawa N., Adewole I.F., Knoppers B.M., Foster M.W., Clayton E.W., Watkin J., Gibbs R.A., Muzny D., Nazareth L., Sodergren E., Weinstock G.M., Yakub I., Gabriel S.B., Onofrio R.C., Ziaugra L., Birren B.W., Daly M.J., Wilson R.K., Fulton L.L., Rogers J., Burton J., Carter N.P., Clee C.M., Griffiths M., Jones M.C., McLay K., Plumb R.W., Ross M.T., Sims S.K., Willey D.L., Chen Z., Han H., Kang L., Godbout M., Wallenburg J.C., L'Archeveque P., Bellemare G., Saeki K., Wang H., An D., Fu H., Li Q., Wang Z., Wang R., Holden A.L., Brooks L.D., McEwen J.E., Bird C.R., Guyer M.S., Nailer P.J., Wang V.O., Peterson J.L., Shi M., Spiegel J., Sung L.M., Witonsky J., Zacharia L.F., Collins F.S., Kennedy K., Jamieson R. and Stewart J. (2005) A haplotype map of the human genome. Nature, 437 7063: 1299-1320. doi:10.1038/nature04226

Author Belmont J.W.
Boudreau A.
Leal S.M.
Hardenbol P.
Pasternak S.
Wheeler D.A.
Willis T.D.
Yu F.
Yang H.
Gao Y.
Hu H.
Hu W.
Li C.
Lin W.
Liu S.
Pan H.
Tang X.
Wang J.
Wang W.
Yu J.
Zhang B.
Zhang Q.
Zhao H.
Zhou J.
Barry R.
Blumenstiel B.
Camargo A.
Defelice M.
Faggart M.
Goyette M.
Gupta S.
Moore J.
Nguyen H.
Parkin M.
Roy J.
Stahl E.
Winchester E.
Altshuler D.
Shen Y.
Yao Z.
Huang W.
Chu X.
He Y.
Jin L.
Liu Y.
Shen Y.
Sun W.
Wang H.
Wang Y.
Wang Y.
Xiong X.
Xu L.
Waye M.M.Y.
Tsui S.K.W.
Xue H.
Wong J.T.-F.
Galver L.M.
Fan J.-B.
Murray S.S.
Oliphant A.R.
Chee M.S.
Montpetit A.
Chagnon F.
Ferretti V.
Leboeuf M.
Olivier J.-F.
Phillips M.S.
Roumy S.
Sallee C.
Verner A.
Hudson T.J.
Frazer K.A.
Ballinger D.G.
Cox D.R.
Hinds D.A.
Stuve L.L.
Kwok P.-Y.
Cai D.
Koboldt D.C.
Miller R.D.
Pawlikowska L.
Taillon-Miller P.
Xiao M.
Tsui L.-C.
Mak W.
Sham P.C.
Song Y.Q.
Tam P.K.H.
Nakamura Y.
Kawaguchi T.
Kitamoto T.
Morizono T.
Nagashima A.
Ohnishi Y.
Sekine A.
Tanaka T.
Deloukas P.
Bird C.P.
Delgado M.
Dermitzakis E.T.
Gwilliam R.
Hunt S.
Morrison J.
Powell D.
Stranger B.E.
Whittaker P.
Bentley D.R.
De Bakker P.I.W.
Barrett J.
Fry B.
Maller J.
McCarroll S.
Patterson N.
Pe'er I.
Purcell S.
Richter D.J.
Sabeti P.
Saxena R.
Schaffner S.F.
Varilly P.
Stein L.D.
Krishnan L.
Smith A.V.
Thorisson G.A.
Chakravarti A.
Chen P.E.
Cutler D.J.
Kashuk C.S.
Lin S.
Abecasis G.R.
Guan W.
Munro H.M.
Qin Z.S.
Thomas D.J.
McVean G.
Bottolo L.
Eyheramendy S.
Freeman C.
Marchini J.
Myers S.
Spencer C.
Stephens M.
Donnelly P.
Cardon L.R.
Clarke G.
Evans D.M.
Morris A.P.
Weir B.S.
Tsunoda T.
Mullikin J.C.
Sherry S.T.
Feolo M.
Zhang H.
Zeng C.
Zhao H.
Matsuda I.
Fukushima Y.
Macer D.R.
Suda E.
Rotimi C.N.
Adebamowo C.A.
Ajayi I.
Aniagwu T.
Marshall P.A.
Nkwodimmah C.
Royal C.D.M.
Leppert M.F.
Dixon M.
Peiffer A.
Qiu R.
Kent A.
Kato K.
Niikawa N.
Adewole I.F.
Knoppers B.M.
Foster M.W.
Clayton E.W.
Watkin J.
Gibbs R.A.
Muzny D.
Nazareth L.
Sodergren E.
Weinstock G.M.
Yakub I.
Gabriel S.B.
Onofrio R.C.
Ziaugra L.
Birren B.W.
Daly M.J.
Wilson R.K.
Fulton L.L.
Rogers J.
Burton J.
Carter N.P.
Clee C.M.
Griffiths M.
Jones M.C.
McLay K.
Plumb R.W.
Ross M.T.
Sims S.K.
Willey D.L.
Chen Z.
Han H.
Kang L.
Godbout M.
Wallenburg J.C.
L'Archeveque P.
Bellemare G.
Saeki K.
Wang H.
An D.
Fu H.
Li Q.
Wang Z.
Wang R.
Holden A.L.
Brooks L.D.
McEwen J.E.
Bird C.R.
Guyer M.S.
Nailer P.J.
Wang V.O.
Peterson J.L.
Shi M.
Spiegel J.
Sung L.M.
Witonsky J.
Zacharia L.F.
Collins F.S.
Kennedy K.
Jamieson R.
Stewart J.
Title A haplotype map of the human genome
Journal name Nature   Check publisher's open access policy
ISSN 0028-0836
Publication date 2005-10-27
Year available 2005
Sub-type Article (original research)
DOI 10.1038/nature04226
Open Access Status Not yet assessed
Volume 437
Issue 7063
Start page 1299
End page 1320
Total pages 22
Place of publication LONDON
Language eng
Subject 1000 General
Abstract Inherited genetic variation has a critical but as yet largely uncharacterized role in human disease. Here we report a public database of common variation in the human genome: more than one million single nucleotide polymorphisms (SNPs) for which accurate and complete genotypes have been obtained in 269 DNA samples from four populations, including ten 500-kilobase regions in which essentially all information about common DNA variation has been extracted. These data document the generality of recombination hotspots, a block-like structure of linkage disequilibrium and low haplotype diversity, leading to substantial correlations of SNPs with many of their neighbours. We show how the HapMap resource can guide the design and analysis of genetic association studies, shed light on structural variation and recombination, and identify loci that may have been subject to natural selection during human evolution.
Keyword Multidisciplinary Sciences
Science & Technology - Other Topics
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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