New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

Horikoshi M., Yaghootkar H., Mook-Kanamori D.O., Sovio U., Taal H.R., Hennig B.J., Bradfield J.P., St Pourcain B., Evans D.M., Charoen P., Kaakinen M., Cousminer D.L., Lehtimaki T., Kreiner-Moller E., Warrington N.M., Bustamante M., Feenstra B., Berry D.J., Thiering E., Pfab T., Barton S.J., Shields B.M., Kerkhof M., Van Leeuwen E.M., Fulford A.J., Kutalik Z., Zhao J.H., Den Hoed M., Mahajan A., Lindi V., Goh L.-K., Hottenga J.-J., Wu Y., Raitakari O.T., Harder M.N., Meirhaeghe A., Ntalla I., Salem R.M., Jameson K.A., Zhou K., Monies D.M., Lagou V., Kirin M., Heikkinen J., Adair L.S., Alkuraya F.S., Al-Odaib A., Amouyel P., Andersson E.A., Bennett A.J., Blakemore A.I.F., Buxton J.L., Dallongeville J., Das S., De Geus E.J.C., Estivill X., Flexeder C., Froguel P., Geller F., Godfrey K.M., Gottrand F., Groves C.J., Hansen T., Hirschhorn J.N., Hofman A., Hollegaard M.V., Hougaard D.M., Hypponen E., Inskip H.M., Isaacs A., Jorgensen T., Kanaka-Gantenbein C., Kemp J.P., Kiess W., Kilpelainen T.O., Klopp N., Knight B.A., Kuzawa C.W., Mcmahon G., Newnham J.P., Niinikoski H., Oostra B.A., Pedersen L., Postma D.S., Ring S.M., Rivadeneira F., Robertson N.R., Sebert S., Simell O., Slowinski T., Tiesler C.M.T., Tonjes A., Vaag A., Viikari J.S., Vink J.M., Vissing N.H., Wareham N.J., Willemsen G., Witte D.R., Zhang H., Zhao J., Wilson J.F., Stumvoll M., Prentice A.M., Meyer B.F., Pearson E.R., Boreham C.A.G., Cooper C., Gillman M.W., Dedoussis G.V., Moreno L.A., Pedersen O., Saarinen M., Mohlke K.L., Boomsma D.I., Saw S.-M., Lakka T.A., Korner A., Loos R.J.F., Ong K.K., Vollenweider P., Van Duijn C.M., Koppelman G.H., Hattersley A.T., Holloway J.W., Hocher B., Heinrich J., Power C., Melbye M., Guxens M., Pennell C.E., Bonnelykke K., Bisgaard H., Eriksson J.G., Widen E., Hakonarson H., Uitterlinden A.G., Pouta A., Lawlor D.A., Smith G.D., Frayling T.M., McCarthy M.I., Grant S.F.A., Jaddoe V.W.V., Jarvelin M.-R., Timpson N.J., Prokopenko I. and Freathy R.M. (2013) New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. Nature Genetics, 45 1: 76-82. doi:10.1038/ng.2477


Author Horikoshi M.
Yaghootkar H.
Mook-Kanamori D.O.
Sovio U.
Taal H.R.
Hennig B.J.
Bradfield J.P.
St Pourcain B.
Evans D.M.
Charoen P.
Kaakinen M.
Cousminer D.L.
Lehtimaki T.
Kreiner-Moller E.
Warrington N.M.
Bustamante M.
Feenstra B.
Berry D.J.
Thiering E.
Pfab T.
Barton S.J.
Shields B.M.
Kerkhof M.
Van Leeuwen E.M.
Fulford A.J.
Kutalik Z.
Zhao J.H.
Den Hoed M.
Mahajan A.
Lindi V.
Goh L.-K.
Hottenga J.-J.
Wu Y.
Raitakari O.T.
Harder M.N.
Meirhaeghe A.
Ntalla I.
Salem R.M.
Jameson K.A.
Zhou K.
Monies D.M.
Lagou V.
Kirin M.
Heikkinen J.
Adair L.S.
Alkuraya F.S.
Al-Odaib A.
Amouyel P.
Andersson E.A.
Bennett A.J.
Blakemore A.I.F.
Buxton J.L.
Dallongeville J.
Das S.
De Geus E.J.C.
Estivill X.
Flexeder C.
Froguel P.
Geller F.
Godfrey K.M.
Gottrand F.
Groves C.J.
Hansen T.
Hirschhorn J.N.
Hofman A.
Hollegaard M.V.
Hougaard D.M.
Hypponen E.
Inskip H.M.
Isaacs A.
Jorgensen T.
Kanaka-Gantenbein C.
Kemp J.P.
Kiess W.
Kilpelainen T.O.
Klopp N.
Knight B.A.
Kuzawa C.W.
Mcmahon G.
Newnham J.P.
Niinikoski H.
Oostra B.A.
Pedersen L.
Postma D.S.
Ring S.M.
Rivadeneira F.
Robertson N.R.
Sebert S.
Simell O.
Slowinski T.
Tiesler C.M.T.
Tonjes A.
Vaag A.
Viikari J.S.
Vink J.M.
Vissing N.H.
Wareham N.J.
Willemsen G.
Witte D.R.
Zhang H.
Zhao J.
Wilson J.F.
Stumvoll M.
Prentice A.M.
Meyer B.F.
Pearson E.R.
Boreham C.A.G.
Cooper C.
Gillman M.W.
Dedoussis G.V.
Moreno L.A.
Pedersen O.
Saarinen M.
Mohlke K.L.
Boomsma D.I.
Saw S.-M.
Lakka T.A.
Korner A.
Loos R.J.F.
Ong K.K.
Vollenweider P.
Van Duijn C.M.
Koppelman G.H.
Hattersley A.T.
Holloway J.W.
Hocher B.
Heinrich J.
Power C.
Melbye M.
Guxens M.
Pennell C.E.
Bonnelykke K.
Bisgaard H.
Eriksson J.G.
Widen E.
Hakonarson H.
Uitterlinden A.G.
Pouta A.
Lawlor D.A.
Smith G.D.
Frayling T.M.
McCarthy M.I.
Grant S.F.A.
Jaddoe V.W.V.
Jarvelin M.-R.
Timpson N.J.
Prokopenko I.
Freathy R.M.
Title New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1061-4036
1546-1718
Publication date 2013-01-01
Year available 2012
Sub-type Article (original research)
DOI 10.1038/ng.2477
Open Access Status Not yet assessed
Volume 45
Issue 1
Start page 76
End page 82
Total pages 10
Place of publication New York, United States
Publisher Nature Publishing Group
Language eng
Abstract Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood(1). Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits(2). In an expanded genome-wide association metaanalysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism.
Formatted abstract
Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism.
Keyword Genetics & Heredity
Genetics & Heredity
GENETICS & HEREDITY
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 126925
BMRC 06/1/21/19/466
MOP-82893
RD08/0003704
3.4.01.26
HEALTH-F4-2007-201413
QLG1-CT-2000-01643
230374
EU/QLRT-2001-01254
(1999SGR) 00241
01 AK 803 A-H
KO3512/1
CB06/02/0041
B27
5031343
6-FY09-507
74882
403981
U01DK062418
RK/2008.024
5R01HL087679-02
1RL1MH083268-01
5R01MH63706: 02
NIMH U24 MH068457-06
Middelgroot-911-09-032
SAF2008-00357
33CSCO-122661
75617
GR069224
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
UQ Diamantina Institute Publications
 
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