Cube - An online tool for comparison and contrasting of protein sequences

Zhang Z.H., Khoo A.A. and Mihalek I. (2013) Cube - An online tool for comparison and contrasting of protein sequences. PLoS ONE, 8 11: 79480.1-79480.5. doi:10.1371/journal.pone.0079480

Author Zhang Z.H.
Khoo A.A.
Mihalek I.
Title Cube - An online tool for comparison and contrasting of protein sequences
Journal name PLoS ONE   Check publisher's open access policy
ISSN 1932-6203
Publication date 2013-11-20
Year available 2013
Sub-type Article (original research)
DOI 10.1371/journal.pone.0079480
Open Access Status DOI
Volume 8
Issue 11
Start page 79480.1
End page 79480.5
Total pages 5
Place of publication San Francisco, United States
Publisher Public Library of Science (PLoS)
Language eng
Subject 1100 Agricultural and Biological Sciences
1300 Biochemistry, Genetics and Molecular Biology
2700 Medicine
Abstract When comparing sequences of similar proteins, two kinds of questions can be asked, and the related two kinds of inference made. First, one may ask to what degree they are similar, and then, how they differ. In the first case one may tentatively conclude that the conserved elements common to all sequences are of central and common importance to the protein's function. In the latter case the regions of specialization may be discriminative of the function or binding partners across subfamilies of related proteins. Experimental efforts - mutagenesis or pharmacological intervention - can then be pointed in either direction, depending on the context of the study. Cube simplifies this process for users that already have their favorite sets of sequences, and helps them collate the information by visualization of the conservation and specialization scores on the sequence and on the structure, and by spreadsheet tabulation. All information can be visualized on the spot, or downloaded for reference and later inspection. Server homepage:
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2014 Collection
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Citation counts: TR Web of Science Citation Count  Cited 1 times in Thomson Reuters Web of Science Article | Citations
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