Persistent prelimbic cortex activity contributes to enhanced learned fear expression in females

Fenton, Georgina E., Pollard, Amelia K, Halliday, David M., Mason, Rob, Bredy, Timothy W. and Stevenson, Carl W. (2014) Persistent prelimbic cortex activity contributes to enhanced learned fear expression in females. Learning and Memory, 21 2: 55-60. doi:10.1101/lm.033514.113


Author Fenton, Georgina E.
Pollard, Amelia K
Halliday, David M.
Mason, Rob
Bredy, Timothy W.
Stevenson, Carl W.
Title Persistent prelimbic cortex activity contributes to enhanced learned fear expression in females
Journal name Learning and Memory   Check publisher's open access policy
ISSN 1072-0502
1549-5485
Publication date 2014-05-01
Year available 2014
Sub-type Article (original research)
DOI 10.1101/lm.033514.113
Open Access Status DOI
Volume 21
Issue 2
Start page 55
End page 60
Total pages 6
Place of publication Woodbury, United States
Publisher Cold Spring Harbor Laboratory Press
Language eng
Abstract Anxiety disorders, such as post-traumatic stress, are more prevalent in women and are characterized by impaired inhibition of learned fear and medial prefrontal cortex (mPFC) dysfunction. Here we examined sex differences in fear extinction and mPFC activity in rats. Females showed more learned fear expression during extinction and its recall, but not fear conditioning. They also showed more spontaneous fear recovery and more contextual fear before extinction and its recall. Moreover, enhanced learned fear expression in females was associated with sustained prelimbic (PL) cortex activity. These results suggest that sex differences in learned fear expression may involve persistent PL activation.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2015 Collection
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 19 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 20 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 11 Mar 2014, 10:52:07 EST by System User on behalf of Queensland Brain Institute