Caffeine intake and risk of basal cell and squamous cell carcinomas of the skin in an 11-year prospective study

Miura, Kyoko, Hughes, Maria Celia B., Green, Adele C. and Van Der Pols, Jolieke C. (2014) Caffeine intake and risk of basal cell and squamous cell carcinomas of the skin in an 11-year prospective study. European Journal of Nutrition, 53 2: 511-520. doi:10.1007/s00394-013-0556-0


Author Miura, Kyoko
Hughes, Maria Celia B.
Green, Adele C.
Van Der Pols, Jolieke C.
Title Caffeine intake and risk of basal cell and squamous cell carcinomas of the skin in an 11-year prospective study
Journal name European Journal of Nutrition   Check publisher's open access policy
ISSN 1436-6207
1436-6215
Publication date 2014-03-01
Year available 2013
Sub-type Article (original research)
DOI 10.1007/s00394-013-0556-0
Volume 53
Issue 2
Start page 511
End page 520
Total pages 10
Place of publication Heidelberg, Germany
Publisher Springer Medizin
Collection year 2014
Language eng
Formatted abstract
Purpose: Caffeine may repair skin damage induced by excessive exposure to ultraviolet light. The purpose of this study was to investigate the association between caffeine intake and incidence of basal cell (BCC) and squamous cell carcinoma (SCC). We also assessed the associations between coffee consumption and incidence of these skin cancers.
Methods: Caffeine intake and consumption of coffee were estimated from food frequency questionnaires assessed in 1992, 1994, and 1996 among 1,325 randomly selected adult residents of a subtropical Australian community. All histologically confirmed tumours of BCC and SCC occurring between 1997 and 2007 were recorded. Associations with BCC and SCC were assessed using Poisson and negative binomial regression models and were adjusted for confounders including skin type and indicators of past sun exposure.
Results: There was no association between total caffeine intake and incidence of BCC or SCC. Participants with prior skin cancers, however, had a 25 % lower risk of BCC if they were in the highest tertile of total caffeine intake (equivalent to daily consumption of four cups of regular coffee) compared with the lowest tertile (multivariable RR 0.75; 95 % CI 0.57-0.97, P trend = 0.025). There was no dose-response relationship with SCC. Consumption of neither caffeinated nor decaffeinated coffee was associated with BCC or SCC.
Conclusions: Among people with prior skin cancers, a relatively high caffeine intake may help prevent subsequent BCC development. However, caffeine intake appears not to influence the risk of SCC.
Keyword Basal cell carcinoma
Caffeine
Coffee
Non-melanoma skin cancer
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online 4 July 2013

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Public Health Publications
 
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