Enlarged perivascular spaces and cerebral small vessel disease

Potter, Gillian M., Doubal, Fergus N., Jackson, Caroline A., Chappell, Francesca M., Sudlow, Cathie L., Dennis, Martin S. and Wardlaw, Joanna M. (2013) Enlarged perivascular spaces and cerebral small vessel disease. International Journal of Stroke, 10 3: 376-381. doi:10.1111/ijs.12054

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Author Potter, Gillian M.
Doubal, Fergus N.
Jackson, Caroline A.
Chappell, Francesca M.
Sudlow, Cathie L.
Dennis, Martin S.
Wardlaw, Joanna M.
Title Enlarged perivascular spaces and cerebral small vessel disease
Journal name International Journal of Stroke   Check publisher's open access policy
ISSN 1747-4930
Publication date 2013-05-22
Sub-type Article (original research)
DOI 10.1111/ijs.12054
Open Access Status Not yet assessed
Volume 10
Issue 3
Start page 376
End page 381
Total pages 6
Place of publication Richmond, VIC, Australia
Publisher Wiley-Blackwell Publishing Asia
Language eng
Formatted abstract
Background and aims Enlarged perivascular spaces (also known as Virchow–Robin spaces) on T2-weighted brain magnetic resonance imaging are common, but their etiology, and specificity to small vessel as opposed to general cerebrovascular disease or ageing, is unclear. We tested the association between enlarged perivascular spaces and ischemic stroke subtype, other markers of small vessel disease, and common vascular risk factors.

Methods We prospectively recruited patients with acute stroke, diagnosed and subtyped by a stroke physician using clinical features and brain magnetic resonance imaging. A neuroradiologist rated basal ganglia and centrum semiovale enlarged perivascular spaces on a five-point scale, white matter lesions, recent and old infarcts, and cerebral atrophy. We assessed associations between basal ganglia-, centrum semiovale- and total (combined basal ganglia and centrum semiovale) enlarged perivascular spaces, stroke subtype, white matter lesions, atrophy, and vascular risk factors.

Results Among 298 patients (mean age 68 years), after adjusting for vascular risk factors and white matter lesions, basal ganglia–enlarged perivascular spaces were associated with increasing age (P = 0·001), centrum semiovale–enlarged perivascular spaces (P < 0·001), cerebral atrophy (P = 0·03), and lacunar stroke subtype (P = 0·04). Centrum semiovale–enlarged perivascular spaces were associated mainly with basal ganglia–enlarged perivascular spaces. Total enlarged perivascular spaces were associated with increasing age (P = 0·01), deep white matter lesions (P = 0·005), and previous stroke (P = 0·006).

Conclusions Enlarged perivascular spaces are associated with age, lacunar stroke subtype and white matter lesions and should be considered as another magnetic resonance imaging marker of cerebral small vessel disease. Further evaluation of enlarged perivascular spaces in studies of ageing, stroke, and dementia is needed to determine their pathophysiological importance.
Keyword Brain
Cerebral infarction
Stroke subtypes
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Article first published online: 22 MAY 2013

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Public Health Publications
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Citation counts: TR Web of Science Citation Count  Cited 18 times in Thomson Reuters Web of Science Article | Citations
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Created: Sat, 08 Mar 2014, 02:02:00 EST by Caroline Jackson on behalf of School of Public Health