Molecular inversion probe-based SPR biosensing for specific, label-free and real-time detection of regional DNA methylation

Carrascosa, Laura G., Sina, Abu Ali Ibn, Palanisamy, Ramkumar, Sepulveda, Borja, Otte, Marinus A., Rauf, Sakandar, Shiddiky, Muhamad J. A. and Trau, Matt (2014) Molecular inversion probe-based SPR biosensing for specific, label-free and real-time detection of regional DNA methylation. Chemical Communications, 50 27: 3585-3588. doi:10.1039/C3CC49607D

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Author Carrascosa, Laura G.
Sina, Abu Ali Ibn
Palanisamy, Ramkumar
Sepulveda, Borja
Otte, Marinus A.
Rauf, Sakandar
Shiddiky, Muhamad J. A.
Trau, Matt
Title Molecular inversion probe-based SPR biosensing for specific, label-free and real-time detection of regional DNA methylation
Journal name Chemical Communications   Check publisher's open access policy
ISSN 1359-7345
1364-548X
Publication date 2014-02-11
Sub-type Article (original research)
DOI 10.1039/C3CC49607D
Open Access Status File (Author Post-print)
Volume 50
Issue 27
Start page 3585
End page 3588
Total pages 4
Place of publication Cambridge, United Kingdom
Publisher R S C Publications
Collection year 2015
Language eng
Abstract DNA methylation has the potential to be a clinically important biomarker in cancer. This communication reports a real-time and label-free biosensing strategy for DNA methylation detection in the cancer cell line. This has been achieved by using surface plasmon resonance biosensing combined with the highly specific molecular inversion probe based amplification method, which requires only 50 ng of bisulfite treated genomic DNA.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Fri, 07 Mar 2014, 20:19:07 EST by Laura Garcia Carrascosa on behalf of Aust Institute for Bioengineering & Nanotechnology