alpha-Catenin cytomechanics: role in cadherin-dependent adhesion and mechanotransduction

Barry, Adrienne K., Tabdili, Hamid, Muhamed, Ismaeel, Wu, Jun, Shashikanth, Nitesh, Gomez, Guillermo A., Yap, Alpha S., Gottardi, Cara J., de Rooij, Johan, Wang, Ning and Leckband, Deborah E. (2014) alpha-Catenin cytomechanics: role in cadherin-dependent adhesion and mechanotransduction. Journal of Cell Science, Advance Online Article 8: 1-42. doi:10.1242/jcs.139014

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Author Barry, Adrienne K.
Tabdili, Hamid
Muhamed, Ismaeel
Wu, Jun
Shashikanth, Nitesh
Gomez, Guillermo A.
Yap, Alpha S.
Gottardi, Cara J.
de Rooij, Johan
Wang, Ning
Leckband, Deborah E.
Title alpha-Catenin cytomechanics: role in cadherin-dependent adhesion and mechanotransduction
Formatted title
α-Catenin cytomechanics: role in cadherin-dependent adhesion and mechanotransduction
Journal name Journal of Cell Science   Check publisher's open access policy
ISSN 0021-9533
1477-9137
Publication date 2014-02-12
Year available 2014
Sub-type Article (original research)
DOI 10.1242/jcs.139014
Open Access Status File (Publisher version)
Volume Advance Online Article
Issue 8
Start page 1
End page 42
Total pages 42
Place of publication Cambridge, United Kingdom
Publisher The Company of Biologists
Language eng
Formatted abstract
These findings demonstrate the role of α-catenin in cadherin-based adhesion and mechanotransduction, in different mechanical contexts. Bead-twisting measurements in conjunction with imaging, and the use of different cell lines and α-catenin mutants reveal that the acute, local mechanical manipulation of cadherin bonds triggers vinculin and actin recruitment to cadherin adhesions, in an actin- and α-catenin-dependent manner. The modest effect of α-catenin on two-dimensional binding affinities of cell surface cadherins further suggests that force-activated adhesion strengthening is due to enhanced cadherin/cytoskeletal interactions rather than to α-catenin-dependent affinity modulation. Complementary investigations of cadherin-based rigidity sensing also suggest that, although α-catenin alters traction force generation, it is not the sole regulator of cell contractility on compliant, cadherin-coated substrata.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Advance Online Article February 12, 2014

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
Institute for Molecular Bioscience - Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 41 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 43 times in Scopus Article | Citations
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Created: Wed, 05 Mar 2014, 01:32:53 EST by Susan Allen on behalf of Institute for Molecular Bioscience