Gonococcal antimicrobial resistance in the Western Pacific Region

Lahra, Monica M, Lo, Ying-Ru and Whiley, David M (2013) Gonococcal antimicrobial resistance in the Western Pacific Region. Sexually Transmitted Infections, 89 SUPPL. 4: iv19-iv23. doi:10.1136/sextrans-2012-050906

Author Lahra, Monica M
Lo, Ying-Ru
Whiley, David M
Title Gonococcal antimicrobial resistance in the Western Pacific Region
Journal name Sexually Transmitted Infections   Check publisher's open access policy
ISSN 1368-4973
Publication date 2013-12-01
Year available 2013
Sub-type Article (original research)
DOI 10.1136/sextrans-2012-050906
Open Access Status Not Open Access
Volume 89
Issue SUPPL. 4
Start page iv19
End page iv23
Total pages 5
Place of publication London, United Kingdom
Publisher B M J Group
Language eng
Formatted abstract
Objective To outline the current situation of gonococcal antimicrobial resistance (AMR) in the Western Pacific region and factors that impact on this.

Background The Western Pacific region is densely populated with many living in poverty. There are high rates of infectious diseases, and a disproportionate burden of gonococcal disease. In many countries there is uncontrolled antimicrobial use: these are ideal conditions for the emergence of AMR.

Methods Gonococcal AMR in this region has been monitored for more than 20 years. Clinical isolates, predominantly from unselected patients attending sexually transmitted diseases clinics, are tested against a panel of antibiotics. Quality assurance and control strategies are in place.

Results There is widespread, high level resistance to penicillin and ciprofloxacin. Decreased susceptibility to ceftriaxone (MIC≥0.06 mg/L) is reported in high levels from some countries in the region. Low numbers of isolates tested in some countries reflect capacity for testing, and are suboptimal for surveillance.

Conclusion The raised MIC values to ceftriaxone, and the emergence and spread of ceftriaxone resistant strains regionally is alarming. Sustaining and enhancing surveillance is critical; however obtaining an adequate sample size is a long-standing issue. The implementation of molecular surveillance strategies could provide broader information on the spread and threat of AMR.

Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

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