Killer immunoglobulin-like receptor and their HLA ligands in Guillain-Barré Syndrome

Blum, Stefan, Csurhes, Peter, Reddel, Stephen, Spies, Judy and McCombe, Pamela (2014) Killer immunoglobulin-like receptor and their HLA ligands in Guillain-Barré Syndrome. Journal of Neuroimmunology, 267 1-2: 92-96. doi:10.1016/j.jneuroim.2013.12.007


Author Blum, Stefan
Csurhes, Peter
Reddel, Stephen
Spies, Judy
McCombe, Pamela
Title Killer immunoglobulin-like receptor and their HLA ligands in Guillain-Barré Syndrome
Journal name Journal of Neuroimmunology   Check publisher's open access policy
ISSN 0165-5728
1872-8421
Publication date 2014-01-01
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.jneuroim.2013.12.007
Open Access Status Not Open Access
Volume 267
Issue 1-2
Start page 92
End page 96
Total pages 5
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Abstract Guillain-Barré Syndrome (GBS) is an inflammatory neuropathy that occurs in some individuals after exposure to an infectious illness. We investigated the role of Killer-immunoglobulin-like receptors (KIR) and their HLA ligands as potential genetic factors in the pathogenesis of GBS. These receptors are involved in the innate immune response to infections.Whilst no significant differences in the frequencies KIR genes were found, HLA-C2 and HLA-B Bw4-T were more frequent in subjects with GBS than controls (p. <. 0.001). The inhibitory pairs KIR-2DL2/HLA-C2 and KIR-3DL1/HLA-B Bw4-T were more frequent in GBS than controls (all p. <. 0.005).We propose that NK cell inhibition is an important factor in the pathogenesis of GBS.
Keyword Gene frequency
Guillain-Barré syndrome
Histocompatibility antigens, Class I
Killer cells, Natural
Receptors, KIR
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2015 Collection
School of Medicine Publications
 
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