Prevalence and severity of oral disease in adults with chronic kidney disease: a systematic review of observational studies

Ruospo, Marinella, Palmer, Suetonia C., Craig, Jonathan C., Gentile, Giorgio, Johnson, David W., Ford, Pauline J., Tonelli, Marcello, Petruzzi, Massimo, De Benedittis, Michele and Strippoli, Giovanni F.M. (2014) Prevalence and severity of oral disease in adults with chronic kidney disease: a systematic review of observational studies. Nephrology Dialysis Transplantation, 29 2: 364-375. doi:10.1093/ndt/gft401


Author Ruospo, Marinella
Palmer, Suetonia C.
Craig, Jonathan C.
Gentile, Giorgio
Johnson, David W.
Ford, Pauline J.
Tonelli, Marcello
Petruzzi, Massimo
De Benedittis, Michele
Strippoli, Giovanni F.M.
Title Prevalence and severity of oral disease in adults with chronic kidney disease: a systematic review of observational studies
Journal name Nephrology Dialysis Transplantation   Check publisher's open access policy
ISSN 0931-0509
1460-2385
Publication date 2014-02-01
Year available 2013
Sub-type Article (original research)
DOI 10.1093/ndt/gft401
Open Access Status DOI
Volume 29
Issue 2
Start page 364
End page 375
Total pages 12
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Language eng
Abstract Background. Oral disease may be increased in people with chronic kidney disease (CKD) and, due to associations with inflammation and malnutrition, represents a potential modifiable risk factor for cardiovascular disease and mortality. We summarized the prevalence of oral disease in adults with CKD and explored any association between oral disease and mortality.
Formatted abstract
Background. Oral disease may be increased in people with chronic kidney disease (CKD) and, due to associations with inflammation and malnutrition, represents a potential modifiable risk factor for cardiovascular disease and mortality. We summarized the prevalence of oral disease in adults with CKD and explored any association between oral disease and mortality.
Methods.
We used systematic review of observational studies evaluating oral health in adults with CKD identified in MEDLINE (through September 2012) without language restriction. We summarized prevalence and associations with all-cause and cardiovascular mortality using random-effects meta-analysis. We explored for sources of heterogeneity between studies using meta-regression.
Results.
Eighty-eight studies in 125 populations comprising 11 340 adults were eligible. Edentulism affected one in five adults with CKD Stage 5D (dialysis) {20.6% [95% confidence interval (CI), 16.4-25.6]}. Periodontitis was more common in CKD Stage 5D [56.8% (CI, 39.3-72.8)] than less severe CKD [31.6% (CI, 19.0-47.6)], although data linking periodontitis with premature death were scant. One-quarter of patients with CKD Stage 5D reported never brushing their teeth [25.6% (CI, 10.2-51.1)] and a minority used dental floss [11.4% (CI, 6.2-19.8)]; oral pain was reported by one-sixth [18.7% (CI, 8.8-35.4)], while half of patients experienced a dry mouth [48.4% (CI, 37.5-59.5)]. Data for kidney transplant recipients and CKD Stages 1-5 were limited.
Conclusions.
Oral disease is common in adults with CKD, potentially reflects low use of preventative dental services, and may be an important determinant of health in this clinical setting.
Keyword Chronic kidney disease
Epidemiology
Meta-analysis
Oral health
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online 29 September 2013

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Dentistry Publications
School of Medicine Publications
 
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