Wnt5a induces Ryk-dependent and -independent effects on callosal axon and dendrite growth

Clark, Charlotte E. J., Richards, , Linda J., Stacker, Steven A. and Cooper, Helen M. (2014) Wnt5a induces Ryk-dependent and -independent effects on callosal axon and dendrite growth. Growth Factors, 32 1: 11-17. doi:10.3109/08977194.2013.875544

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
UQ324598_OA.pdf Full text (open access) application/pdf 109.34KB 0

Author Clark, Charlotte E. J.
Richards, , Linda J.
Stacker, Steven A.
Cooper, Helen M.
Title Wnt5a induces Ryk-dependent and -independent effects on callosal axon and dendrite growth
Journal name Growth Factors   Check publisher's open access policy
ISSN 0897-7194
Publication date 2014-02-01
Year available 2014
Sub-type Article (original research)
DOI 10.3109/08977194.2013.875544
Open Access Status File (Author Post-print)
Volume 32
Issue 1
Start page 11
End page 17
Total pages 7
Place of publication London, United Kingdom
Publisher Informa Healthcare
Language eng
Subject 1308 Clinical Biochemistry
1310 Endocrinology
1307 Cell Biology
Abstract The non-canonical Wnt receptor, Ryk, promotes chemorepulsive axon guidance in the developing mouse brain and spinal cord in response to Wnt5a. Ryk has also been identified as a major suppressor of axonal regrowth after spinal cord injury. Thus, a comprehensive understanding of how growing axons and dendrites respond to Wnt5a-mediated Ryk activation is required if we are to overcome this detrimental activity. Here we undertook a detailed analysis of the effect of Wnt5a/Ryk interactions on axonal and dendritic growth in dissociated embryonic mouse cortical neuron cultures, focusing on callosal neurons known to be responsive to Ryk-induced chemorepulsion. We show that Ryk inhibits axonal growth in response to Wnt5a. We also show that Wnt5a inhibits dendrite growth independently of Ryk. However, this inhibition is relieved when Ryk is present. Therefore, Wnt5a-mediated Ryk activation triggers divergent responses in callosal axons and dendrites in the in vitro context.
Keyword Axon outgrowth
Dendrite outgrowth
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 456040
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2015 Collection
School of Biomedical Sciences Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 5 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 04 Mar 2014, 10:48:47 EST by System User on behalf of Queensland Brain Institute