Paediatric end-stage renal disease in a tertiary hospital in South West Nigeria

Asinobi, Adanze O., Ademola, Adebowale D., Ogunkunle, Oluwatoyin O. and Mott, Susan A. (2014) Paediatric end-stage renal disease in a tertiary hospital in South West Nigeria. BMC Nephrology, 15 1: 25.1-25.9. doi:10.1186/1471-2369-15-25


Author Asinobi, Adanze O.
Ademola, Adebowale D.
Ogunkunle, Oluwatoyin O.
Mott, Susan A.
Title Paediatric end-stage renal disease in a tertiary hospital in South West Nigeria
Journal name BMC Nephrology   Check publisher's open access policy
ISSN 1471-2369
Publication date 2014-02-03
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1186/1471-2369-15-25
Open Access Status DOI
Volume 15
Issue 1
Start page 25.1
End page 25.9
Total pages 9
Place of publication London, United Kingdom
Publisher BioMed Central Ltd.
Language eng
Subject 2727 Nephrology
Abstract Background: Children and adolescents with end-stage renal disease (ESRD) in sub-Saharan Africa may have the worst outcomes globally. Barriers to management include late presentation, poor socioeconomic conditions, absence of medical insurance, limited diagnostic facilities and non-availability of chronic renal replacement therapy (RRT). Our study was to determine the incidence, aetiology, management and outcomes of paediatric ESRD in a tertiary hospital in Nigeria. Methods. A retrospective case review of paediatric ESRD at the University College Hospital Ibadan, Nigeria, over 8 years, from January 2005 to December 2012. Results: 53 patients (56.6% male), median age 11 (inter quartile range 8.5-12) years were studied. Mean annual incidence of ESRD in Ibadan for children aged 14 years and below was 4 per million age related population (PMARP) while for those aged 5-14 years it was 6.0 PMARP. Glomerulonephritis was the cause in 41 (77.4%) patients amongst whom, 29 had chronic glomerulonephritis and 12 had nephrotic syndrome. Congenital anomalies of the kidneys and urinary tract (CAKUT) accounted for 11 (21.2%) cases, posterior urethral valves being the most common. Acute haemodialysis, acute peritoneal dialysis or a combination of these were performed in 33 (62.3%), 6 (11.3%) and 4 (7.5%) patients respectively. Median survival was 47 days and in-hospital mortality was 59%. Conclusions: Incidence of paediatric ESRD in Ibadan is higher than previous reports from sub-Saharan Africa. Glomerulonephritis, and then CAKUT are the most common causes. Mortality is high, primarily due to lack of resources. Preventive nephrology and chronic RRT programmes are urgently needed.
Keyword Chronic kidney disease
Congenital anomalies of the kidneys and urinary tract
End stage renal disease (ESRD)
Glomerulonephritis
Nephrotic syndrome
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
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