Multimodal polymer nanoparticles with combined 19F magnetic resonance and optical detection for tunable, targeted, multimodal imaging in vivo

Rolfe, Barbara E., Blakey, Idriss, Squires, Oliver, Peng, Hui, Boase, Nathan R. B., Alexander, Cameron, Parsons, Peter G., Boyle, Glen M., Whittaker, Andrew K. and Thurecht, Kristofer J. (2014) Multimodal polymer nanoparticles with combined 19F magnetic resonance and optical detection for tunable, targeted, multimodal imaging in vivo. Journal of the American Chemical Society, 136 6: 2413-2419. doi:10.1021/ja410351h


Author Rolfe, Barbara E.
Blakey, Idriss
Squires, Oliver
Peng, Hui
Boase, Nathan R. B.
Alexander, Cameron
Parsons, Peter G.
Boyle, Glen M.
Whittaker, Andrew K.
Thurecht, Kristofer J.
Title Multimodal polymer nanoparticles with combined 19F magnetic resonance and optical detection for tunable, targeted, multimodal imaging in vivo
Journal name Journal of the American Chemical Society   Check publisher's open access policy
ISSN 0002-7863
1520-5126
Publication date 2014-02-12
Year available 2014
Sub-type Article (original research)
DOI 10.1021/ja410351h
Open Access Status Not yet assessed
Volume 136
Issue 6
Start page 2413
End page 2419
Total pages 7
Place of publication Washington, DC United States
Publisher American Chemical Society
Language eng
Subject 1600 Chemistry
1503 Business and Management
1303 Specialist Studies in Education
1505 Marketing
Abstract Understanding the complex nature of diseased tissue in vivo requires development of more advanced nanomedicines, where synthesis of multifunctional polymers combines imaging multimodality with a biocompatible, tunable, and functional nanomaterial carrier. Here we describe the development of polymeric nanoparticles for multimodal imaging of disease states in vivo. The nanoparticle design utilizes the abundant functionality and tunable physicochemical properties of synthetically robust polymeric systems to facilitate targeted imaging of tumors in mice. For the first time, high-resolution 19F/1H magnetic resonance imaging is combined with sensitive and versatile fluorescence imaging in a polymeric material for in vivo detection of tumors. We highlight how control over the chemistry during synthesis allows manipulation of nanoparticle size and function and can lead to very high targeting efficiency to B16 melanoma cells, both in vitro and in vivo. Importantly, the combination of imaging modalities within a polymeric nanoparticle provides information on the tumor mass across various size scales in vivo, from millimeters down to tens of micrometers.
Keyword Chemistry, Multidisciplinary
Chemistry
CHEMISTRY, MULTIDISCIPLINARY
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID FT110100284
Institutional Status UQ

 
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