Dosage effects of BDNF Val66Met polymorphism on cortical surface area and functional connectivity

Wang, Chao, Zhang, Yuanchao, Liu, Bing, Long, Haixia, Yu, Chunshui and Jiang, Tianzi (2014) Dosage effects of BDNF Val66Met polymorphism on cortical surface area and functional connectivity. Journal of Neuroscience, 34 7: 2645-2651. doi:10.1523/JNEUROSCI.3501-13.2014

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Author Wang, Chao
Zhang, Yuanchao
Liu, Bing
Long, Haixia
Yu, Chunshui
Jiang, Tianzi
Title Dosage effects of BDNF Val66Met polymorphism on cortical surface area and functional connectivity
Journal name Journal of Neuroscience   Check publisher's open access policy
ISSN 0270-6474
Publication date 2014-02-01
Year available 2014
Sub-type Article (original research)
DOI 10.1523/JNEUROSCI.3501-13.2014
Open Access Status File (Publisher version)
Volume 34
Issue 7
Start page 2645
End page 2651
Total pages 7
Place of publication Washington, DC, United States
Publisher Society for Neuroscience
Language eng
Abstract The single nucleotide polymorphism (SNP) that leads to a valine-to-methionine substitution at codon 66 (Val66Met) in BDNF is correlated with differences in cognitive and memory functions, as well as with several neurological and psychiatric disorders.MRIstudies have already shown that this genetic variant contributes to changes in cortical thickness and volume, but whether the Val66Met polymorphism affects the cortical surface area of healthy subjects remains unclear. Here, we used multimodal MRI to study whether this polymorphism would affect the cortical morphology and resting-state functional connectivity of a large sample of healthy Han Chinese human subjects. An SNP-wise general linear model analysis revealed a "dosage effect" of the Met allele, specifically a stepwise increase in cortical surface area of the right anterior insular cortex with increasing numbers of the Met allele. Moreover, we found enhanced functional connectivity between the anterior insular and the dorsolateral prefrontal cortices that was linked with the dosage of the Met allele. In conclusion, these data demonstrated a "dosage effect" ofBDNFVal66Met on normal cortical structure and function, suggesting anewpath for exploring the mechanisms underlying the effects of genotype on cognition.
Keyword Anterior insula
Brain-derived neurotrophic factor (BDNF)
Functional connectivity
Surface area
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2015 Collection
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Citation counts: TR Web of Science Citation Count  Cited 14 times in Thomson Reuters Web of Science Article | Citations
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