Dendritic cells as targets or therapeutics in rheumatic autoimmune disease

Thomas, Ranjeny (2014) Dendritic cells as targets or therapeutics in rheumatic autoimmune disease. Current Opinion in Rheumatology, 26 2: 211-218. doi:10.1097/BOR.0000000000000032


Author Thomas, Ranjeny
Title Dendritic cells as targets or therapeutics in rheumatic autoimmune disease
Journal name Current Opinion in Rheumatology   Check publisher's open access policy
ISSN 1040-8711
1531-6963
Publication date 2014-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1097/BOR.0000000000000032
Volume 26
Issue 2
Start page 211
End page 218
Total pages 8
Place of publication Philadelphia, PA, United States
Publisher Lippincott Williams & Wilkins
Language eng
Formatted abstract
Purpose of Review: Antigen-specific immunotherapy is a major goal for improvement in the treatment of autoimmune rheumatic disease. Dendritic cells are professional antigen-presenting cells, abundant at mucosal surfaces and in tissues. They also play a critical role in self-tolerance. This review covers recent advances in the field of dendritic cells as targets or therapeutics in rheumatic autoimmune disease.

Recent Findings: Key themes include the phenotypic and functional characterization, lineage relationships and transcription factors involved in the development of the various dendritic cell subsets. Phenotype and function of mouse and human subsets has now been much better mapped. Progress in the elucidation of targeting ligands and routes for induction of antigen-specific tolerance using either antigen-antibody fusion constructs or particulate conjugates is described. Various inflammatory molecules made by dendritic cells, including type I interferon, are important therapeutic targets in autoimmune rheumatic diseases. Approaches to block this and clinical trials in this area are discussed.

Summary: There are considerable basic science developments in the field of dendritic cells and tolerance that will speed translation to human of the large amount of knowledge generated in mouse in-vivo systems. Various antigen-specific therapy approaches are in the process of translation to the clinic.
Keyword Antigens
Autoimmune disease
Dendritic cells
Tolerance
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
UQ Diamantina Institute Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
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