Clinical prognostic factors and survival outcome in renal cell carcinoma patients - a Malaysian single centre perspective

Yap, Ning Yi, Ng, Keng Lim, Ong, Teng Aik, Pailoor, Jayalakshmi, Gobe, Glenda C., Ooi, Chong Chien, Razack, Azad Hassan, Dublin, Norman, Morais, Christudas and Rajandram, Retnagowri (2013) Clinical prognostic factors and survival outcome in renal cell carcinoma patients - a Malaysian single centre perspective. Asian Pacific Journal of Cancer Prevention, 14 12: 7497-7500. doi:10.7314/APJCP.2013.14.12.7497

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Author Yap, Ning Yi
Ng, Keng Lim
Ong, Teng Aik
Pailoor, Jayalakshmi
Gobe, Glenda C.
Ooi, Chong Chien
Razack, Azad Hassan
Dublin, Norman
Morais, Christudas
Rajandram, Retnagowri
Title Clinical prognostic factors and survival outcome in renal cell carcinoma patients - a Malaysian single centre perspective
Journal name Asian Pacific Journal of Cancer Prevention   Check publisher's open access policy
ISSN 1513-7368
Publication date 2013-01-01
Sub-type Article (original research)
DOI 10.7314/APJCP.2013.14.12.7497
Volume 14
Issue 12
Start page 7497
End page 7500
Total pages 4
Place of publication Bangkok, Thailand
Publisher Asian Pacific Organization for Cancer Prevention
Language eng
Formatted abstract
Background: This study concerns clinical characteristics and survival of renal cell carcinoma (RCC) patients in University Malaya Medical Centre (UMMC), as well as the prognostic significance of presenting symptoms.

Materials and Methods: The clinical characteristics, presenting symptoms and survival of RCC patients (n=151) treated at UMMC from 2003-2012 were analysed. Symptoms evaluated were macrohaematuria, flank pain, palpable abdominal mass, fever, lethargy, loss of weight, anaemia, elevated ALP, hypoalbuminemia and thrombocytosis. Univariate and multivariate Cox regression analyses were performed to determine the prognostic significance of these presenting symptoms. Kaplan Meier and log rank tests were employed for survival analysis.

Results: The 2002 TNM staging was a prognostic factor (p<0.001) but Fuhrman grading was not significantly correlated with survival (p=0.088). At presentation, 76.8% of the patients were symptomatic. Generally, symptomatic tumours had a worse survival prognosis compared to asymptomatic cases (p=0.009; HR 4.74). All symptoms significantly affect disease specific survival except frank haematuria and loin pain on univariate Cox regression analysis. On multivariate analysis adjusted for stage, only clinically palpable abdominal mass remained statistically significant (p=0.027). The mean tumour size of palpable abdominal masses, 9.5±4.3cm, was larger than non palpable masses, 5.3±2.7cm (p<0.001).

Conclusions: This is the first report which includes survival information of RCC patients from Malaysia. Here the TNM stage and a palpable abdominal mass were independent predictors for survival. Further investigations using a multicentre cohort to analyse mortality and survival rates may aid in improving management of these patients.
Keyword Prognostic factor
Renal cell carcinoma
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 03 Mar 2014, 00:45:29 EST by Dr Christudas Morais on behalf of Medicine - Princess Alexandra Hospital