The fibrinogen-binding M1 protein reduces pharyngeal cell adherence and colonization phenotypes of M1T1 Group A Streptococcus

Anderson, Ericka L., Cole, Jason N., Olson, Joshua, Ryba, Bryan, Ghosh, Partho and Nizet, Victor (2014) The fibrinogen-binding M1 protein reduces pharyngeal cell adherence and colonization phenotypes of M1T1 Group A Streptococcus. Journal of Biological Chemistry, 289 6: 3539-3546. doi:10.1074/jbc.M113.529537

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Author Anderson, Ericka L.
Cole, Jason N.
Olson, Joshua
Ryba, Bryan
Ghosh, Partho
Nizet, Victor
Title The fibrinogen-binding M1 protein reduces pharyngeal cell adherence and colonization phenotypes of M1T1 Group A Streptococcus
Formatted title
The fibrinogen-binding M1 protein reduces pharyngeal cell adherence and colonization phenotypes of M1T1 Group A Streptococcus 
Journal name Journal of Biological Chemistry   Check publisher's open access policy
ISSN 0021-9258
Publication date 2014-01-01
Sub-type Article (original research)
DOI 10.1074/jbc.M113.529537
Open Access Status File (Publisher version)
Volume 289
Issue 6
Start page 3539
End page 3546
Total pages 8
Place of publication Bethesda, MD, United States
Publisher American Society for Biochemistry and Molecular Biology
Language eng
Formatted abstract
Background: The group A Streptococcus (GAS) M1 protein binds fibrinogen (Fg) to block phagocytosis and to form a proinflammatory complex. Results: M1 and Fg limit GAS adherence and invasion of pharyngeal keratinocytes in vitro.

Conclusion: Protease SpeB modulates M1 expression and GAS host cell interactions differentially during the course of infection.

Significance: M1 protein is shown to impede pharyngeal colonization in vivo
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Chemistry and Molecular Biosciences
 
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Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 9 times in Scopus Article | Citations
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Created: Sat, 01 Mar 2014, 00:48:40 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences