Phosphorylation of soluble tau differs in Pick's disease and Alzheimer's disease brains

van Eersel, Janet, Bi, Mian, Ke, Yazi D., Hodges, John R., Xuereb, John H., Gregory, Gillian C., Halliday, Glenda M., Gotz, Jurgen, Kril, Jillian J. and Ittner, Lars M. (2009) Phosphorylation of soluble tau differs in Pick's disease and Alzheimer's disease brains. Journal of Neural Transmission, 116 10: 1243-1251. doi:10.1007/s00702-009-0293-y


Author van Eersel, Janet
Bi, Mian
Ke, Yazi D.
Hodges, John R.
Xuereb, John H.
Gregory, Gillian C.
Halliday, Glenda M.
Gotz, Jurgen
Kril, Jillian J.
Ittner, Lars M.
Title Phosphorylation of soluble tau differs in Pick's disease and Alzheimer's disease brains
Journal name Journal of Neural Transmission   Check publisher's open access policy
ISSN 0300-9564
Publication date 2009-01-01
Sub-type Article (original research)
DOI 10.1007/s00702-009-0293-y
Open Access Status Not Open Access
Volume 116
Issue 10
Start page 1243
End page 1251
Total pages 9
Place of publication Wien, Austria
Publisher Springer
Language eng
Abstract Frontotemporal lobar degeneration (FTLD) is a common cause of presenile dementia characterised by behavioural and language disturbances. Pick's disease (PiD) is a subtype of FTLD, which presents with intraneuronal inclusions consisting of hyperphosphorylated tau protein aggregates. Although Alzheimer's disease (AD) is also characterised by tau lesions, these are both histologically and biochemically distinct from the tau aggregates found in PiD. What determines the distinct characteristics of these tau lesions is unknown. As phosphorylated, soluble tau has been suggested to be the precursor of tau aggregates, we compared both the level and phosphorylation profile of tau in tissue extracts of AD and PiD brains to determine whether the differences in the tau lesions are reflected by differences in soluble tau. Levels of soluble tau were decreased in AD but not PiD. In addition, soluble tau was phosphorylated to a greater extent in AD than in PiD and displayed a different phosphorylation profile in the two disorders. Consistently, tau kinases were activated to different degrees in AD compared with PiD. Such differences in solubility and phosphorylation may contribute, at least in part, to the formation of distinct tau deposits, but may also have implications for the clinical differences between AD and PiD.
Keyword Alzheimer's disease
ERK
Frontotemporal lobar degeneration
Phosphorylation
Pick's disease
Tau
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
 
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