Target gene repression mediated by miRNAs miR-181c and miR-9 both of which are down-regulated by amyloid-β.

Schonrock, Nicole, Humphreys, David T., Preiss, Thomas and Gotz, Jürgen (2012) Target gene repression mediated by miRNAs miR-181c and miR-9 both of which are down-regulated by amyloid-β.. Journal of Molecular Neuroscience, 46 2: 324-335. doi:10.1007/s12031-011-9587-2


Author Schonrock, Nicole
Humphreys, David T.
Preiss, Thomas
Gotz, Jürgen
Title Target gene repression mediated by miRNAs miR-181c and miR-9 both of which are down-regulated by amyloid-β.
Journal name Journal of Molecular Neuroscience   Check publisher's open access policy
ISSN 0895-8696
1559-1166
Publication date 2012-01-01
Sub-type Article (original research)
DOI 10.1007/s12031-011-9587-2
Open Access Status Not Open Access
Volume 46
Issue 2
Start page 324
End page 335
Total pages 12
Place of publication Totowa, NJ, United States
Publisher Humana Press
Language eng
Formatted abstract
MicroRNAs (miRNAs) are small non-coding RNA regulators of protein synthesis that are essential for normal brain development and function. Their profiles are significantly altered in neurodegenerative diseases such as Alzheimer's disease (AD) that is characterized by amyloid-β (Aβ) and tau deposition in brain. How deregulated miRNAs contribute to AD is not understood, as their dysfunction could be both a cause and a consequence of disease. To address this question we had previously profiled miRNAs in models of AD. This identified miR-9 and -181c as being down-regulated by Aβ in hippocampal cultures. Interestingly, there was a remarkable overlap with those miRNAs that are deregulated in Aβ-depositing APP23 transgenic mice and in human AD tissue. While the Aβ precursor protein APP itself is a target of miRNA regulation, the challenge resides in identifying further targets. Here, we expand the repertoire of miRNA target genes by identifying the 3' untranslated regions (3' UTRs) of TGFBI, TRIM2, SIRT1 and BTBD3 as being repressed by miR-9 and -181c, either alone or in combination. Taken together, our study identifies putative target genes of miRNAs miR-9 and 181c, which may function in brain homeostasis and disease pathogenesis. 
Keyword Alzheimer

Amyloid-β
HeLa cell
microRNA
Neurodegeneration
Sirtuin
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
 
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