Neuroproteomics as a promising tool in Parkinson's disease research

Pienaar, Ilse S., Daniels, William M. U. and Gotz, Jurgen (2008) Neuroproteomics as a promising tool in Parkinson's disease research. Journal of Neural Transmission, 115 10: 1413-1430. doi:10.1007/s00702-008-0070-3


Author Pienaar, Ilse S.
Daniels, William M. U.
Gotz, Jurgen
Title Neuroproteomics as a promising tool in Parkinson's disease research
Journal name Journal of Neural Transmission   Check publisher's open access policy
ISSN 0300-9564
1435-1463
Publication date 2008-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/s00702-008-0070-3
Open Access Status Not Open Access
Volume 115
Issue 10
Start page 1413
End page 1430
Total pages 18
Place of publication Wien, Austria
Publisher Springer
Language eng
Abstract Despite the vast number of studies on Parkinson's disease (PD), its effective diagnosis and treatment remains unsatisfactory. Hence, the relentless search for an optimal cure continues. The emergence of neuroproteomics, with its sophisticated techniques and non-biased ability to quantify proteins, provides a methodology with which to study the changes in neurons that are associated with neurodegeneration. Neuroproteomics is an emerging tool to establish disease-associated protein profiles, while also generating a greater understanding as to how these proteins interact and undergo post-translational modifications. Furthermore, due to the advances made in bioinformatics, insight is created concerning their functional characteristics. In this review, we first summarize the most prominent proteomics techniques and then discuss the major advances in the fast-growing field of neuroproteomics in PD. Ultimately, it is hoped that the application of this technology will lead towards a presymptomatic diagnosis of PD, and the identification of risk factors and new therapeutic targets at which pharmacological intervention can be aimed.
Keyword Alzheimer's disease
Biomarker
Cerebrospinal fluid
Mass spectrometry
Neurodegenerative disease
Neuroproteomics
Parkinson's disease
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Queensland Brain Institute Publications
 
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