Saitohin gene is not associated with Alzheimer's disease

Streffer, J. R., Papassotiropoulos, A., Kurosinski, P., Signorell, A., Wollmer, M. A., Tsolaki, M., Iakovidou, V., Horndli, F., Bosset, J., Gotz, J., Nitsch, R. M. and Hock, C. (2003) Saitohin gene is not associated with Alzheimer's disease. Journal of Neurology, Neurosurgery and Psychiatry, 74 3: 362-363. doi:10.1136/jnnp.74.3.362

Author Streffer, J. R.
Papassotiropoulos, A.
Kurosinski, P.
Signorell, A.
Wollmer, M. A.
Tsolaki, M.
Iakovidou, V.
Horndli, F.
Bosset, J.
Gotz, J.
Nitsch, R. M.
Hock, C.
Title Saitohin gene is not associated with Alzheimer's disease
Journal name Journal of Neurology, Neurosurgery and Psychiatry   Check publisher's open access policy
ISSN 0022-3050
Publication date 2003-03-01
Year available 2003
Sub-type Letter to editor, brief commentary or brief communication
DOI 10.1136/jnnp.74.3.362
Open Access Status Not yet assessed
Volume 74
Issue 3
Start page 362
End page 363
Total pages 2
Place of publication London, United Kingdom
Publisher B M J Group
Language eng
Formatted abstract
Background: The deposition of tau protein in neurofibrillary tangles constitutes an important feature of many neurodegenerative disorders, including Alzheimer's disease. A polymorphic gene, saitohin (STH), nested within the tau gene (microtubule associated protein tau, MAPT), was recently identified and an association of a non-synonymous polymorphism in STH with increased risk for Alzheimer's disease was suggested.

Objective and methods: To test the above hypothesis in a case-control association study of two independent white populations within Switzerland and Greece, comparing genotype and allele frequencies from 225 Alzheimer's disease patients and 144 healthy control subjects.

Results: No differences in allelic or genotypic distributions between Alzheimer's disease patients and controls was found in the individual samples (Swiss/Greek) or in the combined sample. Stratification for the presence of apolipoprotein E (APOE) ε4 allele, sex, or age did not show significant effects in the populations studied, nor was there an effect on the age of onset.

Conclusions: No evidence was found for an association of the non-synonymous polymorphism (Q7R) in STH and Alzheimer's disease. This finding is in line with earlier studies showing no association between MAPT and Alzheimer's disease.
Keyword Clinical Neurology
Neurosciences & Neurology
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Letter to editor, brief commentary or brief communication
Collection: Centre for Ageing Dementia Research Publications
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