P70 S6 kinase mediates tau phosphorylation and synthesis

Pei, Jin-Jing, An, Wen-Lin, Zhou, Xin-Wen, Nishimura, Takeshi, Norberg, Jan, Benedikz, Eirikur, Gotz, Juergen and Winblad, Bengt (2006) P70 S6 kinase mediates tau phosphorylation and synthesis. FEBS Letters, 580 1: 107-114. doi:10.1016/j.febslet.2005.11.059

Author Pei, Jin-Jing
An, Wen-Lin
Zhou, Xin-Wen
Nishimura, Takeshi
Norberg, Jan
Benedikz, Eirikur
Gotz, Juergen
Winblad, Bengt
Title P70 S6 kinase mediates tau phosphorylation and synthesis
Journal name FEBS Letters   Check publisher's open access policy
ISSN 0014-5793
Publication date 2006-01-09
Year available 2005
Sub-type Letter to editor, brief commentary or brief communication
DOI 10.1016/j.febslet.2005.11.059
Open Access Status Not yet assessed
Volume 580
Issue 1
Start page 107
End page 114
Total pages 8
Place of publication Chichester, West Sussex, United Kingdom
Publisher John Wiley & Sons
Language eng
Abstract Currently, we found that the 70-kDa p70 S6 kinase (p70S6K) directly phosphorylates tau at S262, S214, and T212 sites in vitro. By immunoprecipitation, p-p70S6K (T421/S424) showed a close association with p-tau (S262 and S396/404). Zinc-induced p70S6K activation could only upregulate translation of total S6 and tau but not global proteins in SH-SY5Y cells. The requirement of p70S6K activation was confirmed in the SH-SY5Y cells that overexpress wild-type htau40. Level of p-p70S6K (T421/S424) was only significantly correlated with p-tau at S262, S214, and T212, but not T212/S214, in Alzheimer's disease (AD) brains. These suggested that p70S6K might contribute to tau related pathologies in AD brains.
Keyword Alzheimer's disease
P70 S6 kinase
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Letter to editor, brief commentary or brief communication
Collection: Centre for Ageing Dementia Research Publications
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