Impaired spatial reference memory and increased exploratory behavior in P301L tau transgenic mice

Pennanen, L., Wolfer, D. P., Nitsch, R. M. and Gotz, J. (2006) Impaired spatial reference memory and increased exploratory behavior in P301L tau transgenic mice. Genes, Brain and Behavior, 5 5: 369-379. doi:10.1111/j.1601-183X.2005.00165.x


Author Pennanen, L.
Wolfer, D. P.
Nitsch, R. M.
Gotz, J.
Title Impaired spatial reference memory and increased exploratory behavior in P301L tau transgenic mice
Journal name Genes, Brain and Behavior   Check publisher's open access policy
ISSN 1601-1848
1601-183X
Publication date 2006-07-01
Year available 2005
Sub-type Article (original research)
DOI 10.1111/j.1601-183X.2005.00165.x
Open Access Status Not yet assessed
Volume 5
Issue 5
Start page 369
End page 379
Total pages 11
Place of publication Hoboken, NJ, United States
Publisher Wiley-Blackwell Publishing
Language eng
Abstract The neuropathological hallmark shared between Alzheimer's disease (AD) and familial frontotemporal dementia (FTDP-17) are neurofibrillary tangles (NFT) which are composed of filamentous aggregates of the microtubule-associated protein tau. Their formation has been reproduced in transgenic mice, which express the FTDP-17-associated mutation P301L of tau. In these mice, tau aggregates are found in many brain areas including the hippocampus and the amygdala, both of which are characterized by NFT formation in AD. Previous studies using an amygdala-specific test battery revealed an increase in exploratory behavior and an accelerated extinction of conditioned taste aversion in these mice. Here, we assessed P301L mice in behavioral tests known to depend on an intact hippocampus. Morris water maze and Y-maze revealed intact spatial working memory but impairment in spatial reference memory at 6 and 11 months of age. In addition, a modest disinhibition of exploratory behavior at 6 months of age was confirmed in the open field and the elevated O-maze and was more pronounced during aging. Copyright
Keyword Alzheimer's disease
Frontotemporal dementia
Hippocampus
Morris water maze
Neurofibrillary tangles
Spatial reference memory
Tau
Transgenic mice
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Centre for Ageing Dementia Research Publications
 
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