Brief update on different roles of tau in neurodegeneration

Ittner, Arne, Ke, Yazi D., van Eersel, Janet, Gladbach, Amadeus, Gotz, Jurgen and Ittner, Lars M. (2011) Brief update on different roles of tau in neurodegeneration. IUBMB Life, 63 7: 495-502. doi:10.1002/iub.467


Author Ittner, Arne
Ke, Yazi D.
van Eersel, Janet
Gladbach, Amadeus
Gotz, Jurgen
Ittner, Lars M.
Title Brief update on different roles of tau in neurodegeneration
Journal name IUBMB Life   Check publisher's open access policy
ISSN 1521-6543
1521-6551
Publication date 2011-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/iub.467
Open Access Status Not Open Access
Volume 63
Issue 7
Start page 495
End page 502
Total pages 8
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell
Language eng
Abstract Both Alzheimer's disease (AD) and almost every second case of frontotemporal lobar degeneration (FTLD) are characterized by the deposition of hyperphosphorylated forms of the microtubule-associated protein tau in neurons and/or glia. This unifying pathology led to coining the umbrella term "tauopathies" for these conditions. While the deposition of tau ultimately results in the formation of typical histopathological lesions, such as the neurofibrillary tangles (NFTs) in AD, it is now well accepted that tau interferes with normal functions in neurons already before its deposition. Together with the identification of pathogenic mutations in the tau-encoding gene MAPT in FTLD and evidence from a rising number of in vivo animal models a central role of tau in neurodegeneration has emerged. Here, we review the role of pathological tau in axonal transport, mitochondrial respiration, and in mediating amyloid-β toxicity in AD. Furthermore, we review recent findings regarding the spreading of tau pathology throughout the brain as disease progresses.
Keyword Alzheimer's disease
Axonal transport
Frontotemporal lobar degeneration
Mitochondrial dysfunction
Neurofibrillary tangle
Spreading
Synapse
Tau
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Queensland Brain Institute Publications
 
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