How should we optimise cardiac resynchronization therapy?

Stanton, Tony, Hawkins, Nathaniel M., Hogg, Kerry J., Goodfield, Nicholas E. R., Petrie, Mark C. and McMurray, John J. V. (2008) How should we optimise cardiac resynchronization therapy?. European Heart Journal, 29 20: 2458-2472. doi:10.1093/eurheartj/ehn380

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Author Stanton, Tony
Hawkins, Nathaniel M.
Hogg, Kerry J.
Goodfield, Nicholas E. R.
Petrie, Mark C.
McMurray, John J. V.
Title How should we optimise cardiac resynchronization therapy?
Journal name European Heart Journal   Check publisher's open access policy
ISSN 0195-668X
Publication date 2008-01-01
Year available 2008
Sub-type Article (original research)
DOI 10.1093/eurheartj/ehn380
Open Access Status Not yet assessed
Volume 29
Issue 20
Start page 2458
End page 2472
Total pages 5
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Language eng
Subject 2705 Cardiology and Cardiovascular Medicine
Abstract Optimization of cardiac resynchronization therapy is increasingly performed. Numerous methods have been proposed, many being echocardiographic. Both the technique and the timing of optimization are contentious. Whether acute haemodynamic benefits translate into long-term improvements in remodelling, symptoms, or prognosis is unknown. Recent guidelines from the American Society of Echocardiography advocate routine optimization. Here, we objectively review the principles, methods, timing, and evidence supporting optimization. Despite limited validation, optimization was included in landmark clinical trials and is inherent in evidence-based practice. Randomized controlled trials comparing methods are needed, with long-term clinical endpoints. For now, optimization should be performed using the iterative method, according to the CARE-HF protocol.
Keyword Atrioventricular delay
Cardiac resynchronization therapy
Interventricular delay
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 34 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 39 times in Scopus Article | Citations
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Created: Wed, 26 Feb 2014, 18:32:52 EST by Tony Stanton on behalf of Medicine - Princess Alexandra Hospital